879730-44-6
Chemical Structure
EGFR/HER2/CDK9-IN-1
- CAS No.: 879730-44-6
- Formula:C23H21N3O3S2
- Molecular Weight:451.56
IUPAC Name: 4-(2-(2-(benzylthio)-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamide
InChIKey: BBMUYWDZIIQJMA-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(CCN2C(SCC3=CC=CC=C3)=NC4=C(C=CC=C4)C2=O)C=C1)(N)=O
Biological Activity: EGFR/HER2/CDK9-IN-1 (Compound 4) is a potent inhibitor of EGFR/HER2/CDK9 with IC50s of 90.17, 131.39, and 67.04 nM, respectively. EGFR/HER2/CDK9-IN-1 exhibits remarkable antitumor activity[1].
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EGFR/HER2/CDK9-IN-1 | EGFR/HER2/CDK9-IN-1 (Compound 4) is a potent inhibitor of EGFR/HER2/CDK9 with IC50s of 90.17, 131.39, and 67.04 nM, respectively. EGFR/HER2/CDK9-IN-1 exhibits remarkable antitumor activity. | |||||||||||||||||||||
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Keywords