886579-13-1
886579-13-1
Chemical Structure
THRX-194556
- CAS No.: 886579-13-1
- Formula:C28H41N5O5S
- Molecular Weight:559.72
IUPAC Name: N-((1R,3S,5S)-8-((S)-2-hydroxy-3-(4-(methylsulfonyl)piperazin-1-yl)propyl)-8-azabicyclo[3.2.1]octan-3-yl)-1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
InChIKey: ABRIRNSRFVVIJK-KIHHCIJBSA-N
SMILES: O=C1C(C(N[C@@H]2C[C@@H](N3C[C@@H](O)CN4CCN(S(C)(=O)=O)CC4)CC[C@@H]3C2)=O)=CC5=CC=CC=C5N1C(C)C
Biological Activity: THRX-194556 is a 5-HT4 receptor agonist. THRX-194556 can be used to study gastrointestinal functional disorders and Alzheimer’s disease[1][2].
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THRX-194556 | THRX-194556 is a 5-HT4 receptor agonist. THRX-194556 can be used to study gastrointestinal functional disorders and Alzheimer’s disease. | |||||||||||||||||||||
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References
- [1]. A Multivalent Approach to the Design and Discovery of Orally Efficacious 5-HT4 Receptor Agonists J. Med. Chem., 2009, 52 (17), pp 5330-5343
- [2]. Long DD, et al. Discovery, oral pharmacokinetics and in vivo efficacy of velusetrag, a highly selective 5-HT(4) receptor agonist that has achieved proof-of-concept in patients with chronic idiopathic constipation. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6048-52. [Content Brief]
