91-44-1
Chemical Structure
7-Diethylamino-4-methylcoumarin
- CAS No.: 91-44-1
- Formula:C14H17NO2
- Molecular Weight:231.29
IUPAC Name: 7-(diethylamino)-4-methyl-2H-chromen-2-one
InChIKey: AFYCEAFSNDLKSX-UHFFFAOYSA-N
SMILES: O=C1C=C(C)C2=CC=C(N(CC)CC)C=C2O1
Biological Activity: 7-Diethylamino-4-methylcoumarin is a coumarin fluorescent dye, primarily used for the detection of antiandrogenic activity in environmental water samples and for bioaccumulation studies. The detection mechanism of 7-Diethylamino-4-methylcoumarin does not rely on enzymes or pH, but is based on its intrinsic fluorescence properties, producing changes in fluorescence signal upon binding to the androgen receptor or distributing in environments of different polarities (Ex/Em = 410/470 nm)[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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7-Diethylamino-4-methylcoumarin | 99.95% | 7-Diethylamino-4-methylcoumarin is a coumarin fluorescent dye, primarily used for the detection of antiandrogenic activity in environmental water samples and for bioaccumulation studies. The detection mechanism of 7-Diethylamino-4-methylcoumarin does not rely on enzymes or pH, but is based on its intrinsic fluorescence properties, producing changes in fluorescence signal upon binding to the androgen receptor or distributing in environments of different polarities (Ex/Em = 410/470 nm). | ||||||||||||||||||||
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7-Diethylamino-4-methylcoumarin (Standard) | ≥98% | 7-Diethylamino-4-methylcoumarin (Standard) is the analytical standard of 7-Diethylamino-4-methylcoumarin (HY-D0082). This product is intended for research and analytical applications. 7-Diethylamino-4-methylcoumarin is a coumarin fluorescent dye, primarily used for the detection of antiandrogenic activity in environmental water samples and for bioaccumulation studies. The detection mechanism of 7-Diethylamino-4-methylcoumarin does not rely on enzymes or pH, but is based on its intrinsic fluorescence properties, producing changes in fluorescence signal upon binding to the androgen receptor or distributing in environments of different polarities (Ex/Em = 410/470 nm). | ||||||||||||||||||||
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References
- [1]. Hać A, et al. Searching for relationships between the structure of selected simple coumarins, their antioxidant capacity and anticancer properties. Journal of Molecular Structure. 2023 Dec 15;1294:136477.
- [2]. Lai Y, et al. Occurrence, Bioaccumulation, and Human Exposure Risk of the Antiandrogenic Fluorescent Dye 7-(Dimethylamino)-4-methylcoumarin and 7-(Diethylamino)-4-methylcoumarin in the Dongjiang River Basin, South China. Toxics. 2024 Dec 20;12(12):925.
- [3]. Lachowicz-Radulska J, et al. Zebrafish as a Suitable Model for Utilizing the Bioactivity of Coumarins and Coumarin-Based Compounds. International journal of molecular sciences. 2025 Feb 08;26(4):1444.
- [4]. Xia M, et al. Identification of chemical compounds that induce HIF-1alpha activity. Toxicological sciences : an official journal of the Society of Toxicology. 2009 Nov;112(1):153-63.
- [5]. Cha Y, et al. Theranostic Potential of an NAD (P) H‐Activatable Fluorophore: Assessing Cancer Aggressiveness and Triggering Apoptosis. Angewandte Chemie. 2026 Aug 25:e7968058.
