CGS-12066 maleate 

CGS-12066 (maleate) is a 5-HT receptor agonist. CGS-12066 has agonist effect for 5-HT_1A , 5-HT_1B ,5-HT_1C and 5-HT_1D with pEC₅₀ values of 6.41, 7.56, 4.05 and 7.11, respectively. CGS-12066 can be used for the research of neurological disease^[1].

pEC50: 6.41 (5-HT1A), 7.56 (5-HT1B), 4.05 (5-HT1C) and 7.11 (5-HT1D)^[1].
pKD: 7.19 (5-HT1A), 6.94 (5-HT1B), 4.89 (5-HT1C) and 7.49 (5-HT1D)^[1].

CGS-12066 (maleate) has agonist effect for 5-HT_1A, 5-HT_1B,5-HT_1C and 5-HT_1D with pEC₅₀ values of 6.41, 7.56, 4.05 and 7.11, respectively^[1].
CGS-12066 (maleate) has agonist effect for 5-HT_1A, 5-HT_1B,5-HT_1C and 5-HT_1D with pK_D values of 7.19, 6.94, 4.89 and 7.49, respectively^[1].
CGS-12066 (maleate) stimulates accumulation of inositol phosphates with low potency^[1].
CGS-12066 (maleate) acts as partial agonist in inhibiting forskolin-stimulated adenylate cyclase activity in calf substantia nigra^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

450.41

C₂₁H₂₁F₃N₄O₄

1350965-83-1

CN1CCN(CC1)C2=NC3=C(C=CC(C(F)(F)F)=C3)N4C2=CC=C4.O=C(/C=C\C(O)=O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Schoeffter P,et al. Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist?. Naunyn Schmiedebergs Arch Pharmacol. 1989;339(6):675-683.  [Content Brief]