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Art. -Nr.: HY-161466

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AChE-IN-62

AChE-IN-62 (Compound 1) is an effective mixed and selective acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 0.421 μM. AChE-IN-62 exhibits excellent blood-brain barrier permeability and neuroprotective effects. Additionally, AChE-IN-62 can inhibit the aggregation of Aβ_1-42 with an IC₅₀ value of 44.64 μM. AChE-IN-62 is also an effective multi-target-directed ligand (MTDL) that can be utilized in the research of Alzheimer's disease.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₉H₂₁N₅O₃S₂
Molecular Weight:431.53

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

AChE-IN-62 Chemical Structure

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Preis

Verfügbarkeit

Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 0.421 μM (AChE)^[1].

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen :

AChE
BChE

In Vitro

AChE-IN-62 (50 μM; 24-48 h) effectively inhibits the aggregation of Aβ₁₋₄₂ with an IC₅₀ value of 44.64 μM^[1].
AChE-IN-62 (5-20 μM; 24 h) demonstrates neuroprotective effects in SH-SY5Y and Neuro2A cells by ameliorating the neurotoxic effects mediated by H2O2 (200 μM; 24 h) and Okadaic acid (HY-N6785) (30 nM; 24 h)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

SH-SY5Y, Neuro2A
Concentration:

5 μM, 10 μM, 20 μM;
Incubation Time:

24 h
Result:

Inhibited the cell death mediated by H₂O₂ (200 μM; 24 h) and Okadaic acid (HY-N6785).

In Vivo

AChE-IN-62 (Compound 1) (10-20 mg/kg; i.p.; once daily for 7 days) improves the memory decline and learning disabilities induced by Scopolamine (HY-N0296) (3 mg/kg; i.p.; once daily for 7 days) in Swiss albino mice with dementia by repairing the damage to the cortex and hippocampus, thus exerting a protective effect against the harm caused by Scopolamine (HY-N0296)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Dementia model of Swiss albino mice mediated by scopolamine^[1].
Dosage:

5 mg/kg, 10 mg/kg
Administration:

Intraperitoneal injection (i.p.); Once daily for 7 days. Before scopolamine (HY-N0296) treatment (3 mg/kg; i.p.; Once daily for 7 days)
Result:

Reduced the recognition ratio (T2/T1) in mice (a lower T2/T1 value indicates stronger short-term recognition memory).
Significantly enhanced the step-through latency (STL) (a decrease in STL indicates impaired memory).

Chemical Information

Molecular Weight 431.53
Formel C₁₉H₂₁N₅O₃S₂
SMILES

CS(C1=CC=C2C(SC(NC(CN3CCN(C4=CC=CC=N4)CC3)=O)=N2)=C1)(=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mishra CB, et al. Multitarget action of Benzothiazole-piperazine small hybrid molecule against Alzheimer's disease: In silico, In vitro, and In vivo investigation. Biomed Pharmacother. Published online April 1, 2024. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

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CAS. Nr.:
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Reinheit:
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AChE-IN-62

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen