Citrinin-13C13
Based on 1 Customer Validation
Citrinin-13C13 (NSC 186-13C13) is the 13C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98%
- Formel: 13C13H14O5
- Molecular Weight:263.15
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Speicherung:
Solution, -20°C, protect from light, 2 years
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Anwendung
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 518-75-2
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Appearance Liquid
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Molecular Weight 263.15
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Formel 13C13H14O5
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Color Colorless to light yellow
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SMILES
O=[13C]1[13C]([13CH3])=[13C]2[13C@@H]([13CH3])[13C@H]([13CH3])O[13CH]=[13C]2[13C](O)=[13C]1[13C](O)=O
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Synonyms
NSC 186-13C13
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Solution, -20°C, protect from light, 2 years
Reinheit & Dokumentation
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Data Sheet (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-220. [Content Brief]
[2]. de Oliveira Filho JWG, et al, A comprehensive review on biological properties of citrinin. Food Chem Toxicol. 2017 Dec;110:130-141. [Content Brief]
[3]. Čulig B, et al. PRESENCE OF CITRININ IN GRAINS AND ITS POSSIBLE HEALTH EFFECTS. Afr J Tradit Complement Altern Med. 2017 Mar 1;14(3):22-30 [Content Brief]
[4]. Islam MR, et al. Immune modulatory effects of the foodborne contaminant citrinin in mice. Food Chem Toxicol. 2012 Oct;50(10):3537-47. [Content Brief]
[5]. de Oliveira Filho JWG, et al. Citrinin against breast cancer: A cytogenotoxicological study. Phytother Res. 2021 Jan;35(1):504-516. [Content Brief]
[6]. Wu Y, et al. Citrinin exposure affects oocyte maturation and embryo development by inducing oxidative stress-mediated apoptosis. Oncotarget. 2017 May 23;8(21):34525-34533. [Content Brief]
[7]. Nakajima Y, et al. Low doses of the mycotoxin citrinin protect cortical neurons against glutamate-induced excitotoxicity. J Toxicol Sci. 2016 Apr;41(2):311-9. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Citrinin-13C13 Related Classifications
HY-N6746S1 Related Classifications
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