EGFR-IN-141
EGFR-IN-141 (Compound 8I) is the inhibitor for EGFR with an IC50 of 2.67 nM. EGFR-IN-141 exhibits cytotoxicity in cancer cell A549 with an IC50 of 13.75 μM. EGFR-IN-141 induces apoptosis and mitochondrial membrane depolarization, and exhibits potential antitumor efficacy.
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- CAS. Nr.: 3054263-27-0
- Formel: C20H15FN8O2S2
- Molecular Weight:482.51
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
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EGFR 2.67 nM (IC50) |
Chemical Information
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CAS. Nr. 3054263-27-0
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Molecular Weight 482.51
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Formel C20H15FN8O2S2
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SMILES
O=C1C2=C(N=CN1CC3=NN=C(N3N)SCC(NC4=NC5=C(S4)C=C(F)C=C5)=O)C=CC=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)