RCAN2 - regulator of calcineurin 2 Gene

Also Known as CSP2; RCN2; MCIP2; ZAKI4; ZAKI-4; DSCR1L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10231

About RCAN2

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:46,220,736-46,491,970 (from NCBI)

This gene has 3 transcripts (splice variants), 155 orthologues and 2 paralogues. Broad expression in heart (RPKM 64.4), brain (RPKM 36.0) and 18 other tissues.

Summary

This gene encodes a member of the regulator of Calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of Calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

RCAN2 Products (3)

mRNA Protein Name
NM_001251973.2 NP_001238902.1 calcipressin-2 isoform 2
NM_001251974.2 NP_001238903.1 calcipressin-2 isoform 2
NM_005822.4 NP_005813.2 calcipressin-2 isoform 1

RCAN2 Protein Structure

Calcipressin

Calcipressin: Calcipressin (21 - 190)

  • 0
  • 100
  • 197 a.a.
Protein Preferred Names Protein Names

calcipressin-2

  • Down syndrome candidate region 1-like 1

Related Diseases

Diseases Alias
Down Syndrome

  • Trisomy 21

  • Complete Trisomy 21 Syndrome

  • Down'S Syndrome

  • Trisomy 21 Syndrome

  • Down'S Syndrome - Trisomy 21

  • Downs Syndrome

  • G Trisomy

  • 47,Xx,+21

  • 47,Xy,+21

  • Trisomy G

  • Down Syndrome, Susceptibility To

  • Chromosome 21 Trisomy

  • Trisomy 21 Nos

  • Abnormal Autosomes 21
Spastic Paraplegia 6, Autosomal Dominant

  • SPG6

  • Fsp3

  • Hereditary Spastic Paraplegia 6

  • Autosomal Dominant Spastic Paraplegia Type 6

  • Spastic Paraplegia 6

  • Familial Spastic Paraplegia Autosomal Dominant 3

  • Familial Spastic Paraplegia, Autosomal Dominant, 3

  • Autosomal Dominant Familial Spastic Paraplegia Type 3

  • Autosomal Dominant Spastic Paraplegia 6

  • Spastic Paraplegia-6

  • Paraplegia, Spastic, Type 6
Somatization Disorder

  • Somatoform Disorders

  • Briquet'S Disorder

  • Polysomatising Disorder

  • Somatisation Disorder

  • Somatoform Disorder
Shoulder Impingement Syndrome

  • Impingement Syndrome Of Shoulder Region

  • Subacromial Impingement
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11780 RCAN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19234 Rcan2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25723 Rcan2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RCAN2 MGD MGI:1858219
Macaca mulatta RCAN2 VGNC VGNC:82092
Rattus norvegicus RCAN2 RGD RGD:69198
Canis familiaris RCAN2 VGNC VGNC:45437
Felis catus RCAN2 VGNC VGNC:64542
Bos taurus RCAN2 VGNC VGNC:33821
Others RCAN2 NCBI