CD200R1 - CD200 receptor 1 Gene

Also Known as OX2R; MOX2R; CD200R; HCRTR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 131450

About CD200R1

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:112,921,205-112,975,103 (from NCBI)

This gene has 5 transcripts (splice variants), 235 orthologues and 1 paralogue. Broad expression in spleen (RPKM 4.6), placenta (RPKM 2.9) and 22 other tissues.

Summary

This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

CD200R1 Products (4)

mRNA	Protein	Name
NM_138806.4	NP_620161.1	cell surface glycoprotein CD200 receptor 1 isoform a precursor
NM_138939.3	NP_620385.1	cell surface glycoprotein CD200 receptor 1 isoform b precursor
NM_138940.3	NP_620386.1	cell surface glycoprotein CD200 receptor 1 isoform c precursor
NM_170780.3	NP_740750.1	cell surface glycoprotein CD200 receptor 1 isoform d precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cell surface	IDA IDA: Inferred from direct assay	19151626	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD200R1 Protein Structure

C2-set_2

0
100
200
300
325 a.a.

Protein Preferred Names	Protein Names
cell surface glycoprotein CD200 receptor 1	CD200 cell surface glycoprotein receptor

CD200R1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	CD200R1	Q8TD46	CD200	Homo sapiens	P41217	Protein Array	21982860

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD200R1 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P72749	CD200R1 Protein, Human (HEK293, His)	Q8TD46-4 (A27-L266)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75622	CD200R1 Protein, Human (HEK293, His-Fc)	Q8TD46-4 (A27-L266)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P77599	CD200R1 Protein, Human (HEK293, Fc)	Q8TD46-4 (A27-L266)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77600	CD200R1 Protein, Human (HEK293, His-Avi)	Q8TD46-4 (A27-L266)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77601	CD200R1 Protein, Human (Biotinylated, HEK293, His-Avi)	Q8TD46-4 (A27-L266)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78914	CD200R1 Protein, Human (Biotinylated, HEK293, Fc-Avi)	AAQ19772 (A27-L266)	≥ 95%, as determined by reducing SDS-PAGE.

CD200R1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P811002	CD200R Antibody	WB, ICC/IF	Human, Mouse, Rat
HY-P86910	Human CD200R1 Antibody (YA6603)	ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Human Herpesvirus 8	HHV8S Human Herpesvirus 8, Susceptibility To Hhv-8 Hhv-8, Susceptibility To HHV8 Kaposi Sarcoma
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1	Nasu-Hakola Disease Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy Plosl Nhd Presenile Dementia With Bone Cysts Plo-Sl PLOSL1 Dementia, Prefrontal, With Bone Cysts Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease Progressive Dementia With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS18434	Cd200r1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02206	CD200R1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02207	CD200R1L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21271	Cd200r1l Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24915	Cd200r1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27789	Cd200r1l Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P990479	Anti-OX2R/CD200R1 Antibody	Inhibitor	/	Unkown
HY-P991452	Anti-CD200R1/OX2R Antibody (I-4P)	Inhibitor	/	Unkown
HY-P992162	23ME-00610		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CD200R1	RGD	RGD:61837
Macaca mulatta	CD200R1	VGNC	VGNC:70845
Others	CD200R1	NCBI