Fancd2 - Fanconi anemia, complementation group D2 Gene

Also Known as FA4; FAD; FACD; FA-D2; FANCD; 2410150O07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 211651

Summary

Predicted to enable DNA Polymerase binding activity. Acts upstream of or within several processes, including homologous chromosome pairing at meiosis; neuronal stem cell population maintenance; and regulation of regulatory T cell differentiation. Located in condensed chromosome and nucleus. Used to study Fanconi anemia complementation group D2. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group D2; and breast Cancer. Orthologous to human FANCD2 (FA complementation group D2). [provided by Alliance of Genome Resources, Apr 2022]

Fancd2 Products (2)

mRNA Protein Name
NM_001033244.3 NP_001028416.2 Fanconi anemia group D2 protein homolog isoform 1
NM_001347350.1 NP_001334279.1 Fanconi anemia group D2 protein homolog isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
17304220 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
12893777 MGI
acts upstream of or within brain morphogenesis IGI
IGI: Inferred from genetic interaction
24483844 MGI
acts upstream of or within cellular response to oxidative stress IGI
IGI: Inferred from genetic interaction
24483844 MGI
acts upstream of or within gamete generation IMP
IMP: Inferred from mutant phenotype
12893777 MGI
acts upstream of or within homologous chromosome pairing at meiosis IMP
IMP: Inferred from mutant phenotype
12893777 MGI
acts upstream of or within neuronal stem cell population maintenance IGI
IGI: Inferred from genetic interaction
24483844 MGI
acts upstream of or within regulation of CD40 signaling pathway IMP
IMP: Inferred from mutant phenotype
24501220 MGI
acts upstream of or within regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
24501220 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
24501220 MGI
acts upstream of or within regulation of regulatory T cell differentiation IMP
IMP: Inferred from mutant phenotype
24501220 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in condensed chromosome IDA
IDA: Inferred from direct assay
12913077 MGI
located in nucleus IDA
IDA: Inferred from direct assay
24001775 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Fanconi anemia group D2 protein homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-160700 TNG348 Inhibitor 99.74% Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-14520 Tetrahydrofolic acid 96.77% Unkown
HY-123834 FEN1-IN-1 99.85% Unkown
HY-126539 UBE2T/FANCL-IN-1 99.36% Unkown
HY-153365 I-138 Inhibitor 99.75% Unkown
HY-14520A (6S)-Tetrahydrofolic acid / Unkown
HY-RS04735 FANCD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-139621 Colibactin 742 / Unkown
HY-14520B Tetrahydrofolic acid trihydrochloride / Unkown
HY-RS17257 Fancd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23711 Fancd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fancd2 NCBI NCBI:2177