LAMC1 - laminin subunit gamma 1 Gene

Also Known as LAMB2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3915

About LAMC1

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:183,023,420-183,145,592 (from NCBI)

This gene has 6 transcripts (splice variants), 180 orthologues and 27 paralogues. Broad expression in placenta (RPKM 116.1), fat (RPKM 63.0) and 19 other tissues.

Summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. [provided by RefSeq, Aug 2011]

LAMC1 Products (1)

mRNA Protein Name
NM_002293.4 NP_002284.3 laminin subunit gamma-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables extracellular matrix structural constituent IMP
IMP: Inferred from mutant phenotype
15159456 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cell adhesion IDA
IDA: Inferred from direct assay
15159456 GOA
involved in cell migration IMP
IMP: Inferred from mutant phenotype
15561105 GOA
involved in extracellular matrix disassembly IMP
IMP: Inferred from mutant phenotype
15159456 GOA
involved in hemidesmosome assembly IMP
IMP: Inferred from mutant phenotype
15159456 GOA
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
15159456 GOA
involved in substrate adhesion-dependent cell spreading IDA
IDA: Inferred from direct assay
16236823 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in basement membrane IDA
IDA: Inferred from direct assay
14557481 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LAMC1 Protein Structure

Laminin_N

Laminin_N: Laminin N-terminal (Domain VI) (50 - 284)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (286 - 332)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (342 - 395)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (398 - 442)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (445 - 492)

Laminin_B

Laminin_B: Laminin B (Domain IV) (558 - 688)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (724 - 770)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (773 - 816)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (828 - 881)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (884 - 932)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (935 - 980)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (983 - 1027)

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  • 1609 a.a.
Protein Preferred Names Protein Names

laminin subunit gamma-1

  • S-LAM gamma

LAMC1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P81510 Laminin gamma 1 Antibody (YA1255) IHC-P Human
HY-P81510A Laminin gamma 1 Antibody (YA1255)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Junctional Epidermolysis Bullosa

  • Epidermolysis Bullosa, Junctional

  • Jeb

  • Epidermolysis Bullosa Atrophicans

  • Congenital Junctional Epidermolysis Bullosa

  • Epidermolysis Bullosa Junctional

  • Junctional Eb - [Epidermolysis Bullosa]

  • Jeb - [Junctional Epidermolysis Bullosa]

  • Lucidolytic Epidermolysis Bullosa
Diffuse Mesangial Sclerosis

  • Familial Mesangial Sclerosis

  • Mesangial Sclerosis, Diffuse

  • Dms

  • Diffuse Isolated Mesangial Sclerosis

  • Isolated Diffuse Mesangial Sclerosis

  • Nephrotic Syndrome, Early Onset With Diffuse Mesangial Sclerosis
Pelvic Organ Prolapse

  • Rectal Prolapse

  • Pelvic Organ Prolapse, Susceptibility To, 1

  • Pelvic Organ Prolapse, Susceptibility To

  • Prolapse Of Vagina And Rectum

  • Vaginal Prolapse

  • Pelvic Organ Prolapse 1

  • Procidentia, Rectum

  • Prolapse Of Rectal Mucosa

  • Procidentia Of Rectum

  • Rectal Mucosa Prolapse

  • Rectum Prolapse

  • Procidentia Rectum

  • Rp - [Rectal Prolapse]

  • Male Proctocele

  • Male Rectocele

  • Proctoptosis

  • Female Genital Prolapse

  • Female Prolapse

  • Incompetence Of Pelvic Fundus

  • Relaxation Of Perineum

  • Deficiency Of Perineum
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Fuchs' Endothelial Dystrophy

  • Fuchs Endothelial Corneal Dystrophy

  • Fuchs Endothelial Dystrophy

  • Fuchs Dystrophy

  • Fced

  • Fuchs' Corneal Dystrophy

  • Fuchs' Endothelial Corneal Dystrophy

  • Fuchs Atrophy

  • Fuchs Corneal Dystrophy

  • Endoepithelial Corneal Dystrophy

  • Fecd

  • Late Hereditary Endothelial Dystrophy

  • Corneal Dystrophy, Fuchs Endothelial

  • Dystrophy, Corneal, Fuchs Endothelial

  • Corneal Dystrophy, Fuchs' Endothelial, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS07506 LAMC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20440 Lamc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26949 Lamc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LAMC1 MGD MGI:99914
Canis familiaris LAMC1 VGNC VGNC:42571
Felis catus LAMC1 VGNC VGNC:68011
Rattus norvegicus LAMC1 RGD RGD:621052
Macaca mulatta LAMC1 VGNC VGNC:74232
Bos taurus LAMC1 VGNC VGNC:50206
Others LAMC1 NCBI