TRAPPC4 - trafficking protein particle complex subunit 4 Gene

Also Known as SBDN; TRS23; PTD009; CGI-104; HSPC172; NEDESBA; SYNBINDIN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51399

About TRAPPC4

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,018,766-119,024,134 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 214 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 25.2), adrenal (RPKM 22.1) and 25 other tissues.

Summary

Involved in Autophagy and endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPP complex. [provided by Alliance of Genome Resources, Apr 2022]

TRAPPC4 Products (7)

mRNA Protein Name
NM_001318486.2 NP_001305415.1 trafficking protein particle complex subunit 4 isoform 2 precursor
NM_001318488.2 NP_001305417.1 trafficking protein particle complex subunit 4 isoform 3
NM_001318489.2 NP_001305418.1 trafficking protein particle complex subunit 4 isoform 4
NM_001318490.2 NP_001305419.1 trafficking protein particle complex subunit 4 isoform 5
NM_001318492.2 NP_001305421.1 trafficking protein particle complex subunit 4 isoform 6
NM_001318494.2 NP_001305423.1 trafficking protein particle complex subunit 4 isoform 7
NM_016146.6 NP_057230.1 trafficking protein particle complex subunit 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
17110339 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in autophagy IMP
IMP: Inferred from mutant phenotype
31794024 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
31794024 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of TRAPP complex IDA
IDA: Inferred from direct assay
21525244 GOA
part of TRAPP complex IMP
IMP: Inferred from mutant phenotype
31794024 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAPPC4 Protein Structure

Sybindin

Sybindin: Sybindin-like family (3 - 207)

  • 0
  • 100
  • 200
  • 219 a.a.
Protein Preferred Names Protein Names

trafficking protein particle complex subunit 4

  • TRS23 homolog

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Epilepsy, Spasticity, And Brain Atrophy

  • NEDESBA
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies

  • NDMSBA

  • Plaa-Associated Neurodevelopmental Disorder

  • Plaand
Non-Specific Syndromic Intellectual Disability

  • Complex Neurodevelopmental Disorder
Spondyloepiphyseal Dysplasia Tarda, X-Linked

  • Spondyloepiphyseal Dysplasia Tarda

  • X-Linked Spondyloepiphyseal Dysplasia Tarda

  • SEDT

  • Sed Tarda, X-Linked

  • Spondyloepiphyseal Dysplasia, Late

  • Spondyloepiphyseal Dysplasia Tarda X-Linked

  • Sed

  • X Linked Spondyloepiphyseal Dysplasia Tarda

  • X-Linked Spondyloepiphyseal Dysplasia

  • Late Onset Spondyloepiphyseal Dysplasia

  • Sed Tarda

  • X-Linked Sed

  • X-Linked Sedt

  • Dysplasia, Spondyloepiphyseal, Tarda

  • Spondyloepiphyseal Dysplasia
Neu-Laxova Syndrome 2

  • NLS2
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS14991 TRAPPC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19288 Trappc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25778 Trappc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TRAPPC4 MGD MGI:1926211
Felis catus TRAPPC4 VGNC VGNC:66513
Bos taurus TRAPPC4 VGNC VGNC:36290
Rattus norvegicus TRAPPC4 RGD RGD:1302991
Canis familiaris TRAPPC4 VGNC VGNC:47783
Macaca mulatta TRAPPC4 VGNC VGNC:79211
Others TRAPPC4 NCBI