HPF1 - histone PARylation factor 1 Gene

Also Known as C4orf27

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54969

About HPF1

Cytogenetic location: 4q33 Genomic coordinates (GRCh38): 4:169,729,470-169,757,944 (from NCBI)

This gene has 3 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in brain (RPKM 6.3), endometrium (RPKM 6.0) and 25 other tissues.

Summary

Enables chromatin binding activity and histone binding activity. Involved in double-strand break repair; peptidyl-serine ADP-ribosylation; and regulation of protein modification process. Located in chromatin; nucleus; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]

HPF1 Products (1)

mRNA Protein Name
NM_017867.3 NP_060337.2 histone PARylation factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables chromatin binding IDA
IDA: Inferred from direct assay
32939087 GOA
enables histone binding IDA
IDA: Inferred from direct assay
27067600 GOA
enables protein ADP-ribosyltransferase-substrate adaptor activity IDA
IDA: Inferred from direct assay
28190768 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
27067600 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
27067600 GOA
involved in DNA repair IDA
IDA: Inferred from direct assay
32028527 GOA
involved in DNA repair-dependent chromatin remodeling IDA
IDA: Inferred from direct assay
32939087 GOA
involved in double-strand break repair IDA
IDA: Inferred from direct assay
32028527 GOA
involved in regulation of protein ADP-ribosylation IDA
IDA: Inferred from direct assay
33186521 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in chromatin IDA
IDA: Inferred from direct assay
27067600 GOA
located in nucleus IDA
IDA: Inferred from direct assay
27067600 GOA
is active in site of DNA damage IDA
IDA: Inferred from direct assay
32028527 GOA
located in site of DNA damage IDA
IDA: Inferred from direct assay
32939087 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HPF1 Protein Structure

DUF2228

DUF2228: Uncharacterised conserved protein (DUF2228) (77 - 328)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
Protein Preferred Names Protein Names

histone PARylation factor 1

  • UPF0609 protein C4orf27

HPF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
HPF1 Q9NWY4 MKLN1 Homo sapiens Q9UL63
Anti Tag CoIP
33961781
Intra
HPF1 Q9NWY4 MKLN1 Homo sapiens Q9UL63
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures

  • CONDSIAS

  • Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-179042 TGF-β/Smad-IN-3 Inhibitor / Unkown
HY-RS06337 HPF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22203 Hpf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28725 Hpf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HPF1 MGD MGI:1919862
Bos taurus HPF1 VGNC VGNC:56972
Macaca mulatta HPF1 VGNC VGNC:100235
Rattus norvegicus HPF1 RGD RGD:1311747
Canis familiaris HPF1 VGNC VGNC:50635
Felis catus HPF1 VGNC VGNC:78510
Others HPF1 NCBI