PTPN13 - protein tyrosine phosphatase non-receptor type 13 Gene

Also Known as PNP1; FAP-1; PTP1E; PTPL1; PTPLE; PTP-BL; hPTP1E; PTP-BAS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5783

About PTPN13

Cytogenetic location: 4q21.3 Genomic coordinates (GRCh38): 4:86,594,315-86,815,161 (from NCBI)

This gene has 9 transcripts (splice variants), 208 orthologues, 35 paralogues and is associated with 98 phenotypes. Broad expression in skin (RPKM 27.0), ovary (RPKM 14.2) and 18 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]

PTPN13 Products (4)

mRNA	Protein	Name
NM_006264.3	NP_006255.1	tyrosine-protein phosphatase non-receptor type 13 isoform 2
NM_080683.3	NP_542414.1	tyrosine-protein phosphatase non-receptor type 13 isoform 1
NM_080684.3	NP_542415.1	tyrosine-protein phosphatase non-receptor type 13 isoform 3
NM_080685.3	NP_542416.1	tyrosine-protein phosphatase non-receptor type 13 isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables phosphatidylinositol 3-kinase regulatory subunit binding	IPI IPI: Inferred from physical interaction	23604317	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10826496	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	14516276	GOA
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	23604317	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	25893857	GOA
involved in peptidyl-tyrosine dephosphorylation	IMP IMP: Inferred from mutant phenotype	23604317	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	17657516	GOA
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	23604317	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14516276	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	11356191	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10826496	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	14516276	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN13 Protein Structure

FERM_N

FERM_M

FERM_C

PDZ

Y_phosphatase

0
400
800
1200
1600
2000
2485 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein phosphatase non-receptor type 13	fas-associated protein-tyrosine phosphatase 1

PTPN13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PTPN13	Q12923	RAPGEF6	Homo sapiens	Q8TEU7	X-Ray Diffraction	12095257
Intra	PTPN13	Q12923	RAPGEF6	Homo sapiens	Q8TEU7	NMR	14698303
Intra	PTPN13	Q12923	RAPGEF6	Homo sapiens	Q8TEU7	ITC	17240990
Intra	PTPN13	Q12923	FAS	Homo sapiens	P25445	Anti Tag CoIP	12724420
Intra	PTPN13	Q12923	PDCD10	Homo sapiens	Q9BUL8	Y2H	17657516

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Streptococcal Meningitis
Colorectal Cancer, Hereditary Nonpolyposis, Type 6	HNPCC6 Hereditary Nonpolyposis Colorectal Cancer Type 6 Colon Cancer, Hereditary Nonpolyposis, Type 6 Hereditary Non-Polyposis Colorectal Cancer 6 Cancer, Colorectal, Nonpolyposis, Hereditary, Type 6
Rectum Squamous Cell Carcinoma	Squamous Cell Carcinoma Of The Rectum Rectal Squamous Cell Carcinoma Squamous Carcinoma Of Rectum
Cerebral Cavernous Malformations	Cerebral Cavernous Malformation Cavernous Malformations Of Cns And Retina Cerebral Cavernous Malformation 1 Cavernous Angiomatous Malformations Cerebral Capillary Malformations CCM Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations Familial Cavernous Angioma Cavernous Angioma Familial Cerebral Cavernous Malformation Cerebral Cavernous Malformations 1 Cavernous Angioma, Familial Cam Cerebral Cavernous Malformations-1 Cavernoma Central Nervous System Cavernous Hemangioma Cerebral Cavernous Hemangioma Familial Cavernous Hemangioma Familial Cavernous Malformation Familial Cerebral Cavernous Angioma Intracerebral Cavernous Hemangioma CCM1 Cavernous Hemangioma Of The Brain Cerebral Cavernoma Cerebral Cavernous Malformations, Type 1 Hemangioma, Cavernous, Central Nervous System Hemangioma, Cavernous Angioma, Cavernous
Colorectal Cancer, Hereditary Nonpolyposis, Type 4	HNPCC4 Hereditary Nonpolyposis Colorectal Cancer Type 4 Hereditary Non-Polyposis Colorectal Cancer 4 Cancer, Colorectal, Nonpolyposis, Hereditary, Type 4
Subacute Bacterial Endocarditis	Endocarditis Lenta Sbe - Subacute Bacterial Endocarditis Subacute Endocarditis, Lenta Endocarditis, Subacute Bacterial
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Lynch Syndrome I	Lynch Syndrome 1 Colorectal Cancer, Hereditary Nonpolyposis, Type 1 HNPCC1 Fcc1 Lynch Syndrome Ii Colon Cancer, Familial Nonpolyposis, Type 1 Coca1 Familial Nonpolyposis Colon Cancer Type 1 Hereditary Nonpolyposis Colorectal Cancer Type 1 Hereditary Non-Polyposis Colorectal Cancer 1 Hereditary Non-Polyposis Colorectal Cancer 3 Hnpcc3 Lynch Cancer Family Syndrome Lynch Syndrome Lynch Syndrome Type I Lynch Syndrome Type Ii Cancer, Colorectal, Nonpolyposis, Hereditary, Type 1 Hereditary Nonpolyposis Colorectal Cancer Colorectal Cancer, Hereditary Nonpolyposis, Type 3 Hereditary Non-Polyposis Colon Cancer Type 2
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS11418	PTPN13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21180	Ptpn13 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27697	Ptpn13 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PTPN13	VGNC	VGNC:45170
Macaca mulatta	PTPN13	VGNC	VGNC:76599
Mus musculus	PTPN13	MGD	MGI:103293
Felis catus	PTPN13	VGNC	VGNC:69160
Bos taurus	PTPN13	VGNC	VGNC:53774
Rattus norvegicus	PTPN13	RGD	RGD:1563360
Others	PTPN13	NCBI