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Art. -Nr.: HY-N15327

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Hyrtiosal

Hyrtiosal, found in the marine sponge Hyrtios erectus, is an inhibitor of the N-terminal domain (NTD) of HIV-1 integrase (HIV-1 IN) with an IC₅₀ value of 9.60-0.86 μM. Hyrtiosal binds to the Ser17, Trp19, and Lys34 sites on the NTD of HIV-1 IN, inhibiting the binding of HIV-1 viral DNA to integrase and interfering with the formation of the pre-integrated complex of HIV-1. Hyrtiosal is promising for research of anti-HIV agents.

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CAS. Nr.: 138355-07-4
Formel: C₂₅H₃₈O₃
Molecular Weight:386.57

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Hyrtiosal Chemical Structure

CAS. Nr.: 138355-07-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle HIV Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	18 μM Compound: 5	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	[PMID: 19788270]
HuCC-A1	IC₅₀	9.1 μM Compound: 5	Cytotoxicity against human HuCCa1 cells Cytotoxicity against human HuCCa1 cells	[PMID: 19788270]
KB	IC₅₀	7.8 μM Compound: 5	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 19788270]
MDA-MB-231	IC₅₀	5.4 μM Compound: 5	Cytotoxicity against human MDA-MB-231 cells Cytotoxicity against human MDA-MB-231 cells	[PMID: 19788270]
NCI-H69	IC₅₀	31 μM Compound: 5	Cytotoxicity against human adriamycin resistant H69 cells Cytotoxicity against human adriamycin resistant H69 cells	[PMID: 19788270]
T47D	IC₅₀	9.1 μM Compound: 5	Cytotoxicity against human T47D cells Cytotoxicity against human T47D cells	[PMID: 19788270]

Chemical Information

CAS. Nr. 138355-07-4
Molecular Weight 386.57
Formel C₂₅H₃₈O₃
SMILES

C[C@]12[C@@](C[C@@](C)([C@H]2C[C@@H](C3=COC=C3)O)C=O)([H])[C@@]4([C@@](C(C)(CCC4)C)([H])CC1)C
Structure Classification
- Terpenoids
- Other Terpenoids
Initial Source
- Animals
marine sponge Hyrtios erectus
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Du L, et al. Hyrtiosal, from the marine sponge Hyrtios erectus, inhibits HIV-1 integrase binding to viral DNA by a new inhibitor binding site. ChemMedChem. 2008 Jan;3(1):173-80. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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