IL-2-IN-1
Based on 2 publication(s) in Google Scholar
IL-2-IN-1 is a potent IL-2 inhibitor with an IC50 value of 1978 nM. IL-2-IN-1 shows antiproliferative activities.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.95%
- CAS. Nr.: 245747-10-8
- Formel: C17H12F6N4O2
- Molecular Weight:418.29
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) IL-2-IN-1
More
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
IL-2 1978 nM (IC50) |
In Vitro
IL-2-IN-1 (compound 2) shows antiproliferative activities with IC50s of 340, 1266 nM for human PBMC and rat PBMC, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 245747-10-8
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Appearance Solid
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Molecular Weight 418.29
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Formel C17H12F6N4O2
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Color White to off-white
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SMILES
FC(F)(C1=CC(C(F)(F)F)=NN1C2=CC=C(NC(C3=C(ON=C3C)C)=O)C=C2)F
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Proteogenomic Landscape of Breast Ductal Carcinoma Reveals Tumor Progression Characteristics and Therapeutic Targets. [Abstract]2024 Dec;11(46):e2401041. PMID: 39418072 -
Mol Neurobiol
Pharmacological Inhibition of JAK/STAT-IL2 Axis Alleviated Cisplatin-Induced Ototoxicity. [Abstract]2025 Nov 19;63(1):83. PMID: 41254428
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 125 mg/mL (298.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3907 mL | 11.9534 mL | 23.9069 mL | 59.7671 mL |
| 5 mM | 0.4781 mL | 2.3907 mL | 4.7814 mL | 11.9534 mL | |
| 10 mM | 0.2391 mL | 1.1953 mL | 2.3907 mL | 5.9767 mL | |
| 15 mM | 0.1594 mL | 0.7969 mL | 1.5938 mL | 3.9845 mL | |
| 20 mM | 0.1195 mL | 0.5977 mL | 1.1953 mL | 2.9884 mL | |
| 25 mM | 0.0956 mL | 0.4781 mL | 0.9563 mL | 2.3907 mL | |
| 30 mM | 0.0797 mL | 0.3984 mL | 0.7969 mL | 1.9922 mL | |
| 40 mM | 0.0598 mL | 0.2988 mL | 0.5977 mL | 1.4942 mL | |
| 50 mM | 0.0478 mL | 0.2391 mL | 0.4781 mL | 1.1953 mL | |
| 60 mM | 0.0398 mL | 0.1992 mL | 0.3984 mL | 0.9961 mL | |
| 80 mM | 0.0299 mL | 0.1494 mL | 0.2988 mL | 0.7471 mL | |
| 100 mM | 0.0239 mL | 0.1195 mL | 0.2391 mL | 0.5977 mL |
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