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Art. -Nr.: HY-B1733

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Phenyltoloxamine

(Synonyms: Bistrimin; Histionex)

Phenyltoloxamine (Bistrimin) is an antihistamine agent with sedative and analgesic effects. Phenyltoloxamine also has potent Sigma-1 receptor binding affinity (K_i: 160 nM).

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CAS. Nr.: 92-12-6
Formel: C₁₇H₂₁NO
Molecular Weight:255.35

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Data Sheet (271 KB)

Phenyltoloxamine Chemical Structure

CAS. Nr.: 92-12-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
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Biologische Aktivität

Beschreibung

Phenyltoloxamine (Bistrimin) is an antihistamine agent with sedative and analgesic effects. Phenyltoloxamine also has potent Sigma-1 receptor binding affinity (K_i: 160 nM)^[1]^[2]^[3].

IC₅₀ & Target^[3]

Sigma 1 Receptor

160 nM (Ki)

Alle Histamine Receptor Isoform-spezifische Produkte anzeigen :

Alle Sigma Receptor Isoform-spezifische Produkte anzeigen :

Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen :

In Vitro

Phenyltoloxamine (10-50 μM, 24 h) demonstrates cytotoxicity in EVSA-T cells^[2].
Phenyltoloxamine exhibits potent Sigma 1 Receptor (S1R) binding affinity with a K_i value of 160 nM^[3].
Phenyltoloxamine (100 μM) inhibits human liver macrosaml CYP2D6 enzyme by 99.0%^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 92-12-6
Appearance Solid
Molecular Weight 255.35
Formel C₁₇H₂₁NO
SMILES

CN(C)CCOC1=CC=CC=C1CC2=CC=CC=C2
Synonyms

Bistrimin; Histionex
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Justin B.Hoekstra. Pharmacological Properties of a New Antihistaminic Agent, Phenyltoloxamine (Bristamin). Journal of the American Pharmaceutical Association (Scientific ed.). 1953, 42 (10), 587-593.

[2]. Brandes LJ, et al. Evidence that the antiestrogen binding site is a histamine or histamine-like receptor. Biochem Biophys Res Commun. 1985 Jan 31;126(2):905-10. [Content Brief]

[3]. Youyi Peng, et al. Comprehensive 3D-QSAR Model Predicts Binding Affinity of Structurally Diverse Sigma 1 Receptor Ligands. J Chem Inf Model. 2019 Jan 28;59(1):486-497. [Content Brief]

[4]. Sellers, et al. Use of inhibitors of CYP2D6 enzyme for the prevention of drug abuse. Patent, US6124282.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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- In Vitro
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Phenyltoloxamine

Alle Histamine Receptor Isoform-spezifische Produkte anzeigen

Alle Sigma Receptor Isoform-spezifische Produkte anzeigen

Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Phenyltoloxamine Related Classifications

HY-B1733 Related Classifications