Pomalidomide 4'-alkylC5-acid
Based on 1 Customer Validation
Pomalidomide 4'-alkylC5-acid (Example 3) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC5-acid can be used in the synthesis of PROTAC.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.78%
- CAS. Nr.: 2225940-49-6
- Formel: C19H21N3O6
- Molecular Weight:387.39
-
Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
HY-133799
Pomalidomide-C7-COOHCereblon Ligand-linker -
HY-133699
Pomalidomide-PEG4-COOHE3 Ligase Ligand-Linker Conjugate -
HY-135250B
Thalidomide-4-O-C6-NH2 hydrochlorideE3 ligase ligand-linker conjugate -
HY-136184
(S,R,S)-AHPC-phenol-C4-NH2 dihydrochlorideE3 Ligase Ligand-Linker Conjugates -
HY-112618B
Thalidomide-O-amido-C6-NH2 hydrochlorideE3 Ligase Ligand-Linker Conjugates -
HY-136183
(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochlorideE3 Ligase Ligand-Linker Conjugate -
HY-131872
Pomalidomide-PEG2-COOHE3 Ligase Ligand-Linker Conjugate -
HY-128716B
Pomalidomide-PEG3-C2-NH2 hydrochlorideE3 Ligase Ligand-Linker Conjugates -
HY-107438A
Thalidomide-O-amido-C4-NH2 hydrochlorideE3 Ligase Ligand-Linker Conjugates -
HY-131647
Pomalidomide 4'-PEG5-acidE3 Ligase Ligand-Linker Conjugates -
HY-136166
Thalidomide-NH-PEG3-propionic acidE3 Ligase Ligand-Linker Conjugate -
HY-135045
(S,R,S)-AHPC-C4-COOHE3 Ligase Ligand-Linker Conjugate
Alle E3 Ligase Ligand-Linker Conjugates Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Beschreibung
IC50 & Target
|
Cereblon |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 2225940-49-6
-
Appearance Solid
-
Molecular Weight 387.39
-
Formel C19H21N3O6
-
Color Light yellow to yellow
-
SMILES
O=C(O)CCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (129.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
-
Data Sheet (271 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5814 mL | 12.9069 mL | 25.8138 mL | 64.5344 mL |
| 5 mM | 0.5163 mL | 2.5814 mL | 5.1628 mL | 12.9069 mL | |
| 10 mM | 0.2581 mL | 1.2907 mL | 2.5814 mL | 6.4534 mL | |
| 15 mM | 0.1721 mL | 0.8605 mL | 1.7209 mL | 4.3023 mL | |
| 20 mM | 0.1291 mL | 0.6453 mL | 1.2907 mL | 3.2267 mL | |
| 25 mM | 0.1033 mL | 0.5163 mL | 1.0326 mL | 2.5814 mL | |
| 30 mM | 0.0860 mL | 0.4302 mL | 0.8605 mL | 2.1511 mL | |
| 40 mM | 0.0645 mL | 0.3227 mL | 0.6453 mL | 1.6134 mL | |
| 50 mM | 0.0516 mL | 0.2581 mL | 0.5163 mL | 1.2907 mL | |
| 60 mM | 0.0430 mL | 0.2151 mL | 0.4302 mL | 1.0756 mL | |
| 80 mM | 0.0323 mL | 0.1613 mL | 0.3227 mL | 0.8067 mL | |
| 100 mM | 0.0258 mL | 0.1291 mL | 0.2581 mL | 0.6453 mL |
Pomalidomide 4'-alkylC5-acid Related Classifications
HY-130737 Related Classifications
Powered by Bioz