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Romaciclib monohydrochloride (Standard)

(Synonyms: SEL120-34A monohydrochloride (Standard))

Romaciclib monohydrochloride (Standard) is the analytical standard of Romaciclib (monohydrochloride) (HY-111388A). This product is intended for research and analytical applications. SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits Kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50s of 4.4 nM and 10.4 nM, respectively, with a Kd of 3 nM for CDK8. SEL120-34A monohydrochloride weakly inhibits CDK9 (calculated IC50=1070 nM), but shows no obvious activity against CDK1, 2, 4, 6, 5, 7. SEL120-34A monohydrochloride inhibits phosphorylation of STAT1 S727 and STAT5 S726. Has anti-tumor activity.

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  • CAS. Nr.: 2443816-41-7
  • Formel: C15H19Br2ClN4
  • Molecular Weight:450.60
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Romaciclib monohydrochloride (Standard) Chemical Structure
    Romaciclib monohydrochloride (Standard) Chemical Structure
CAS. Nr.: 2443816-41-7
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  • Romaciclib monohydrochloride (Standard) Chemical Structure
    Romaciclib monohydrochloride (Standard) Chemical Structure
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  • Romaciclib monohydrochloride (Standard)