TEAD-IN-10
TEAD-IN-10 (compound 15) has good selective activity and inhibitory effect on TEAD1 (IC50=14 nM), TEAD2 (IC50=179 nM) and TEAD3 (IC50=4 nnM) as a covalent inhibitor. TEAD-IN-10 can be used for cancer research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 3032196-65-6
- Formel: C15H14F3NO
- Molecular Weight:281.27
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
TAED1 14 nM (IC50) |
TAED2 179 nM (IC50) |
TAED3 4 nM (IC50) |
In Vitro
TEAD-IN-10 has a great inhibition for MCF-7 reporter assay (IC50≤10 nM)[1].
TEAD-IN-10 has a great selectivity for TEAD1 and TEAD2 with 97% and 98% inhibition in HEK293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:NCl-H226 and H2052 cell lines
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Concentration:
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Incubation Time:6 days
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Result:The inhibitory effect of H2052 cell line (IC50≤100 nM) was better than that of NCl-H226 cell line (IC50:100-500 nM).
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Cell Line:NCl-H226 and H2052 cell lines
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Concentration:
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Incubation Time:7 days
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Result:The inhibition rate of anti-proliferation of both cell lines was greater than 75%.
Chemical Information
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CAS. Nr. 3032196-65-6
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Molecular Weight 281.27
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Formel C15H14F3NO
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SMILES
O=C(C=C)N(C1)CC1/C=C/C2=CC=C(C(F)(F)F)C=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
TEAD-IN-10 Related Classifications
HY-161568 Related Classifications
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