TRK-IN-12
TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRKG595R IC50 = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC50 = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect (IC50 = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line.
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- CAS. Nr.: 2823342-34-1
- Formel: C18H19ClFN5O3S
- Molecular Weight:439.89
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
0.08 μM
Compound: 9e
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Antiproliferative activity against mouse BaF3 cells harboring LMNA fused NTRKA1
Antiproliferative activity against mouse BaF3 cells harboring LMNA fused NTRKA1
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[PMID: 34628036] |
| BaF3 | IC50 |
0.646 μM
Compound: 9e
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Antiproliferative activity against mouse BaF3 cells harboring LMNA fused NTRKA1 G595R mutant
Antiproliferative activity against mouse BaF3 cells harboring LMNA fused NTRKA1 G595R mutant
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[PMID: 34628036] |
Chemical Information
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CAS. Nr. 2823342-34-1
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Molecular Weight 439.89
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Formel C18H19ClFN5O3S
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SMILES
CN1CC2=CC(F)=CC=C2OCCN(CC3=C4N=C1C=CN4N=C3)S(=O)(CCl)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
TRK-IN-12 Related Classifications
HY-144451 Related Classifications
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