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Art. -Nr.: HY-122324

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Tylophorine

(Synonyms: (+)-(S)-Tylophorine; DCB-3500; NSC-717335)

Tylophorine and its analogs are benzoindole alkaloids, most of which are derived from Garcinia plants. Tylophorine analogs all show potent growth inhibition against human hepatocellular carcinoma HepG2 and human nasopharyngeal carcinoma KB cell lines. Tylophorine analogs can also induce increased albumin expression and inhibit α-fetoprotein expression in HepG2 cells, and have the potential to induce HepG2 cell differentiation.

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CAS. Nr.: 482-20-2
Formel: C₂₄H₂₇NO₄
Molecular Weight:393.48

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Data Sheet (272 KB)

Tylophorine Chemical Structure

CAS. Nr.: 482-20-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	0.7 μM Compound: 2	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 22417638]
CCRF-CEM	GI₅₀	15 nM Compound: DCB-3500, NSC-717335 (+)-S-tylophorine	Growth inhibition of human CEM cells Growth inhibition of human CEM cells	[PMID: 18077159]
HL-60	GI₅₀	0.01 μM Compound: 2	Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay	[PMID: 22417638]
MCF7	GI₅₀	0.042 μM Compound: (S)-tylophorine	Growth inhibition in human MCF7 cells after 72 hrs by alamar blue assay Growth inhibition in human MCF7 cells after 72 hrs by alamar blue assay	[PMID: 22910225]
PANC-1	GI₅₀	12 nM Compound: DCB-3500, NSC-717335 (+)-S-tylophorine	Growth inhibition of human PANC1 cells Growth inhibition of human PANC1 cells	[PMID: 18077159]
RAW264.7	IC₅₀	274 nM Compound: 2	Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay	[PMID: 25221661]
RAW264.7	IC₅₀	78 nM Compound: 2	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA	[PMID: 25221661]
Splenocyte	IC₅₀	1134 nM Compound: 2	Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA	[PMID: 25221661]
Splenocyte	IC₅₀	55 nM Compound: 2	Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA	[PMID: 25221661]

Chemical Information

CAS. Nr. 482-20-2
Appearance Solid
Molecular Weight 393.48
Formel C₂₄H₂₇NO₄
SMILES

COC1=C(C=C2C3=CC(OC)=C(C=C3C4=C(C2=C1)CN5[C@]([H])(C4)CCC5)OC)OC
Synonyms

(+)-(S)-Tylophorine; DCB-3500; NSC-717335
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 44.46 mg/mL (112.99 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5414 mL

12.7071 mL

25.4143 mL

5 mM

0.5083 mL

2.5414 mL

5.0829 mL

10 mM

0.2541 mL

1.2707 mL

2.5414 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Novel Mode of Action of Tylophorine Analogs as Antitumor Compounds

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5414 mL	12.7071 mL	25.4143 mL	63.5356 mL
	5 mM	0.5083 mL	2.5414 mL	5.0829 mL	12.7071 mL
	10 mM	0.2541 mL	1.2707 mL	2.5414 mL	6.3536 mL
	15 mM	0.1694 mL	0.8471 mL	1.6943 mL	4.2357 mL
	20 mM	0.1271 mL	0.6354 mL	1.2707 mL	3.1768 mL
	25 mM	0.1017 mL	0.5083 mL	1.0166 mL	2.5414 mL
	30 mM	0.0847 mL	0.4236 mL	0.8471 mL	2.1179 mL
	40 mM	0.0635 mL	0.3177 mL	0.6354 mL	1.5884 mL
	50 mM	0.0508 mL	0.2541 mL	0.5083 mL	1.2707 mL
	60 mM	0.0424 mL	0.2118 mL	0.4236 mL	1.0589 mL
	80 mM	0.0318 mL	0.1588 mL	0.3177 mL	0.7942 mL
	100 mM	0.0254 mL	0.1271 mL	0.2541 mL	0.6354 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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Tylophorine

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Tylophorine Related Classifications

HY-122324 Related Classifications