AKP-001
AKP-001 is an inhibitor of p38 mitogen-activated protein kinase (p38 MAPK). AKP-001 can inhibit the production of inflammatory cytokines and can be used for research in rheumatoid arthritis and inflammatory bowel disease.
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- CAS No.: 897644-83-6
- Formule: C21H13ClF2N4O2
- Masse moléculaire:426.80
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| THP-1 | IC50 |
49.1 nM
Compound: 26d
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Antiinflammatory activity in human THP1 cells assessed as LPS-induced TNFalpha secretion at 15 uM after 2 hrs by ELISA in presence of 10% fetal calf serum
Antiinflammatory activity in human THP1 cells assessed as LPS-induced TNFalpha secretion at 15 uM after 2 hrs by ELISA in presence of 10% fetal calf serum
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[PMID: 24938496] |
Chemical Information
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CAS No. 897644-83-6
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Masse moléculaire 426.80
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Formule C21H13ClF2N4O2
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SMILES
O=C(NC1=C(C2=NC=NC=C2)C(C3=CC=C(F)C=C3)=NO1)CC4=C(F)C=CC=C4Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AKP-001 Related Classifications
HY-100278 Related Classifications
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