Buloxibutid (Standard)
Buloxibutid (AT2 receptor agonist C21) (Standard) is the analytical standard of Buloxibutid (HY-100113). This product is intended for research and analytical applications. Buloxibutid is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid exerts effects such as vasodilation, anti-inflammation, anti-fibrosis (promoting the expression of collagenase MMP-13) and tissue repair mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway as well as the inflammatory NF-κB pathway. Buloxibutid can be used in research related to idiopathic pulmonary fibrosis, hypertension, and systemic sclerosis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 95%
- CAS No.: 477775-14-7
- Formule: C23H29N3O4S2
- Masse moléculaire:475.62
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- Pureté et documentation
-
Help & FAQs
-
HY-100113
BuloxibutidAT2R Agonist -
HY-17512
LosartanAngiotensin II Receptor Antagonist -
HY-15778
AVE 0991Ang-(1-7) Receptor Agonist -
HY-B0205
CandesartanAngiotensin II AT1-Receptor Blocker -
HY-B0195
TranilastAnti-allergic Agent -
HY-18204
ValsartanAngiotensin II Receptor Antagonist -
HY-13955
TelmisartanAngiotensin II Type 1 Receptor -
HY-17004
OlmesartanAT1R Antagonist -
HY-17505
Candesartan CilexetilAngiotensin II receptor Inhibitor -
HY-13106
OlodanriganAT2R Antagonist -
HY-N0455AS6
L-Arginine-13C6 hydrochlorideStable Isotope -
HY-17512A
Losartan potassiumAT1 Antagonist
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
CAS No. 477775-14-7
-
Masse moléculaire 475.62
-
Formule C23H29N3O4S2
-
SMILES
O=C(OCCCC)NS(=O)(C1=C(C2=CC=C(CN3C=CN=C3)C=C2)C=C(CC(C)C)S1)=O
-
Synonyms
AT2 receptor agonist C21 (Standard)
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Wan Y, et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem. 2004 Nov 18;47(24):5995-6008. [Content Brief]
[2]. Schwengel K, Namsolleck P, Lucht K, et al. Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice. J Mol Med (Berl). 2016;94(8):957-966. [Content Brief]
[3]. Fatima N, Patel S, Hussain T. Angiotensin AT2 Receptor is Anti-inflammatory and Reno-Protective in Lipopolysaccharide Mice Model: Role of IL-10. Front Pharmacol. 2021;12:600163. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Buloxibutid (Standard) Related Classifications
HY-100113R Related Classifications
Powered by Bioz