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Cat. No.: HY-124922

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CBLC100

CBLC100 is an anticancer compound that targets FACT, while inhibiting NF-κB and activating p53. CBLC100 induces cytotoxicity through p53-dependent apoptotic and non-apoptotic pathways. CBLC100 is applicable to the research of cancers such as fibrosarcoma.

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CAS No.: 1197996-83-0
Formule: C₂₄H₂₆N₂O₂
Masse moléculaire:374.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

CBLC100 Chemical Structure

CAS No.: 1197996-83-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

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In Vitro

CBLC100 potently activates p53 and inhibits NF-κB in cell-based reporter gene assays, with corresponding EC₅₀ values of 0.03 μM and 0.06 μM^[1].
CBLC100 exerts selective cytotoxicity against human fibrosarcoma HT1080 cells, while showing low toxicity toward normal human Wi38 diploid fibroblasts^[1].
CBLC100 (0.2 μM; 1 h) traps the FACT complex on the chromatin of human fibrosarcoma HT1080 cells, while depleting soluble FACT subunits in the nucleoplasm^[1].
CBLC100 enhances CK2-mediated phosphorylation of the C-terminal region of p53 in human fibrosarcoma HT1080 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1197996-83-0
Masse moléculaire 374.48
Formule C₂₄H₂₆N₂O₂
SMILES

O=C1CCC2=C1C=CC3=C2C4=C(C=CC5=C4CCC5=O)N3CCN(CC)CC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Gasparian AV, et al. Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT. Sci Transl Med. 2011 Aug 10;3(95):95ra74. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CBLC100

Voir tous les produits spécifiques à Isoform NF-κB

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Chemical Information

Pureté et documentation

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CBLC100 Related Classifications

HY-124922 Related Classifications