MED31 - mediator complex subunit 31 Gene

Also Known as Soh1; CGI-125; 3110004H13Rik

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51003

About MED31

This gene has 4 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in brain (RPKM 6.0), adrenal (RPKM 4.6) and 25 other tissues.

Summary

Predicted to enable transcription coregulator activity and ubiquitin protein Ligase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within limb development and negative regulation of fibroblast proliferation. Predicted to be located in nucleoplasm. Predicted to be part of core mediator complex and mediator complex. [provided by Alliance of Genome Resources, Apr 2022]

MED31 Products (1)

mRNA	Protein	Name
NM_016060.3	NP_057144.1	mediator of RNA polymerase II transcription subunit 31

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15383276	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED31 Protein Structure

Med31

0
100
131 a.a.

Protein Preferred Names	Protein Names
mediator of RNA polymerase II transcription subunit 31	hSOH1

MED31 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	MED31	Q9Y3C7	MED7	Homo sapiens	O43513	Anti Tag CoIP	35271311
Intra	MED31	Q9Y3C7	GADD45G	Homo sapiens	O95257	Pull Down	15383276
Intra	MED31	Q9Y3C7	HTT	Homo sapiens	P42858	Pull Down	15383276
Intra	MED31	Q9Y3C7	HTT	Homo sapiens	P42858	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

MED31 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P89891	Med31 Antibody (YA9235)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human

Related Diseases

Diseases	Alias
Hypermobility Of Coccyx	Coccygeal Hypermobility Syndrome Hypermobility Of The Coccyx
Klippel-Feil Syndrome 3
Superior Mesenteric Artery Syndrome	Wilkie Syndrome Wilkie'S Syndrome Arteriomesenteric Duodenal Compression Syndrome Cast Syndrome Vascular Compression Of The Duodenum Smas Arteriomesenteric Compression Of Duodenojejunal Flexure
Spinal Canal Intradural Extramedullary Neoplasm	Intradural Extramedullary Spinal Tumors Intradural Extramedullary Spinal Canal Neoplasm
Kummell'S Disease	Traumatic Spondylopathy Kummell Disease Kummell'S Spondylitis Kümmelll-Verneuil Disease Kümmell Spondylitis Kümmell Disease Traumatic Spondylosis
Brown-Sequard Syndrome	Brown-Squard Syndrome Hemicord Syndrome Hemiparaplegic Syndrome Hemispinal Cord Syndrome Brown-Séquard Syndrome
Plexopathy
Discitis
Urocanase Deficiency	Encephalopathy Due To Urocanase Deficiency Urocanate Hydratase Deficiency Urocanic Aciduria UROCD High Urine Urocanic Acid Levels
Scheuermann Disease	Scheuermann'S Disease Spinal Osteochondrosis Juvenile Osteochondrosis Of Spine Familial Scheuermann Disease Familial Scheuermann Juvenile Kyphosis Familial Spinal Osteochondrosis Scheuermann Juvenile Kyphosis Juvenile Osteochondritis Of The Spine Juvenile Osteochondrosis Of Scheurermann Scheuermann'S Kyphosis Sherman'S Disease Juvenile Kyphosis Scheuermann Kyphosis [X]Spinal Osteochondrosis, Unspecified
Tarsal Tunnel Syndrome	Neuropathy Of The Posterior Tibial Nerve And Its Branches Posterior Tibial Nerve Neuralgia Compression Of Posterior Tibial Nerve In Tarsal Tunnel
Epidural Abscess	Abscess Epidural
Tibial Neuropathy	Posterior Tibial Neuropathy
Spondylolysis	Acquired Spondylolysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS08302	MED31 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MED31	VGNC	VGNC:99276
Macaca mulatta	MED31	VGNC	VGNC:104630
Mus musculus	MED31	MGD	MGI:1914529
Bos taurus	MED31	VGNC	VGNC:31367
Canis familiaris	MED31	VGNC	VGNC:43138
Rattus norvegicus	MED31	RGD	RGD:1309457
Others	MED31	NCBI