ANKRA2 - ankyrin repeat family A member 2 Gene

Also Known as ANKRA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57763

About ANKRA2

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:73,552,190-73,565,639 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 11.0), endometrium (RPKM 9.3) and 25 other tissues.

Summary

Enables enzyme binding activity and low-density lipoprotein particle receptor binding activity. Involved in regulation of protein-containing complex assembly. Located in cytosol and membrane. Part of protein-containing complex. Colocalizes with 3M complex. [provided by Alliance of Genome Resources, Apr 2022]

ANKRA2 Products (1)

mRNA	Protein	Name
NM_023039.5	NP_075526.1	ankyrin repeat family A protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables histone deacetylase binding	IDA IDA: Inferred from direct assay	22649097	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	22649097	GOA
enables low-density lipoprotein particle receptor binding	IPI IPI: Inferred from physical interaction	22649097	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20873783	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	25752541	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	25752541	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of 3M complex	IDA IDA: Inferred from direct assay	25752541	GOA
located in cytosol	IDA IDA: Inferred from direct assay	11095640	GOA
located in membrane	IDA IDA: Inferred from direct assay	11095640	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	20873783	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANKRA2 Protein Structure

Ank

Ank_2

0
100
200
313 a.a.

Protein Preferred Names	Protein Names
ankyrin repeat family A protein 2	RFXANK-like protein 2

ANKRA2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	ANKRA2	Q9H9E1	SAMD4A	Homo sapiens	Q9UPU9-3	Validated Y2H	32296183
Intra	ANKRA2	Q9H9E1	RFX7	Homo sapiens	Q2KHR2	X-Ray Diffraction	31864703
Intra	ANKRA2	Q9H9E1	RFX7	Homo sapiens	Q2KHR2	Anti Tag CoIP	25752541
Intra	ANKRA2	Q9H9E1	HDAC4	Homo sapiens	P56524	Validated Y2H	25416956
Intra	ANKRA2	Q9H9E1	HDAC4	Homo sapiens	P56524	Y2H Array	25416956
Intra	ANKRA2	Q9H9E1	HDAC4	Homo sapiens	P56524	Y2H Prey Pooling	25416956
Intra	ANKRA2	Q9H9E1	CCDC8	Homo sapiens	Q9H0W5	Anti Tag CoIP	25752541
Intra	ANKRA2	Q9H9E1	HDAC5	Homo sapiens	Q9UQL6	Anti Tag CoIP	25752541
Intra	ANKRA2	Q9H9E1	HDAC5	Homo sapiens	Q9UQL6	Phage Display	35044719

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Three M Syndrome 1	3-M Syndrome Yakut Short Stature Syndrome 3m Syndrome Le Merrer Syndrome Dolichospondylic Dysplasia Gloomy Face Syndrome Three M Syndrome 3M1 3m Syndrome 1 Miller-Mckusick-Malvaux Syndrome 3-Msbn Three-M Slender-Boned Nanism Miller-Mckusick-Malvaux-Syndrome 3-M Syndrome 1 3m Syndrome-1 3m Syndrome, Type 1 Dwarfism Dwarfism Tall Vertebrae
Branchiooculofacial Syndrome	Branchio-Oculo-Facial Syndrome BOFS Bof Syndrome Hemangiomatous Branchial Clefts-Lip Pseudocleft Syndrome Lip Pseudocleft-Hemangiomatous Branchial Cyst Syndrome Branchial Clefts With Characteristic Facies, Growth Retardation, Imperforate Nasolacrimal Duct, And Premature Aging Branchial Clefts With Characteristic Facies Growth Retardation Imperforate Nasolacrimal Duct And Premature Aging Bofs Syndrome Lip Pseudocleft-Hemagiomatous Branchial Cyst Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS00711	ANKRA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ANKRA2	VGNC	VGNC:37879
Felis catus	ANKRA2	VGNC	VGNC:59795
Rattus norvegicus	ANKRA2	RGD	RGD:1303108
Mus musculus	ANKRA2	MGD	MGI:1915808
Bos taurus	ANKRA2	VGNC	VGNC:25907
Macaca mulatta	ANKRA2	VGNC	VGNC:69603
Others	ANKRA2	NCBI