Guavenoic acid
Guavenoic acid is a triterpenoid compound that can be isolated from fresh leaves of Psidium guajava. Guavenoic acid protects cells in cellular oxidative damage models, inhibits intracellular ROS production, and suppresses cell apoptosis. Guavenoic acid significantly enhances cellular proliferation, promotes insulin synthesis and secretion, and upregulates the messenger RNA expression of insulin gene, PDX-1 and MafA. Guavenoic acid can be used in the research of diseases such as pancreatic islet β-cell tumors.
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- CAS No.: 585527-12-4
- Formule: C30H46O6
- Masse moléculaire:502.68
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Guavenoic acid (0.3-30 nM, 48 h) protects cells, inhibits intracellular ROS production, and suppresses cell apoptosis in the H2O2-induced oxidative damage model of INS-1 cells[2].
Guavenoic acid (0.3-30 nM, 48 h) promotes the proliferation of INS-1 cells, enhances cellular insulin synthesis capacity, strengthens both basal insulin secretion and glucose-stimulated insulin secretion functions, and upregulates the mRNA expression levels of insulin gene, PDX-1, and MafA in INS-1 cells under a glucose-stimulated insulin secretion model with glucose concentrations of 5.6 and 16.7 mM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:650 μM H2O2 challenges the INS-1 cells
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Concentration:0.3, 1, 3, 10, 30 nM
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Incubation Time:48 h
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Result:Suppresses cell apoptosis.
Chemical Information
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CAS No. 585527-12-4
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Masse moléculaire 502.68
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Formule C30H46O6
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SMILES
C[C@@]12[C@]3([H])[C@]([C@]4(C([C@@]5([H])[C@@](CC4)(CCC([C@@H]5C)=C)C(O)=O)=CC3)C)(C[C@H]([C@@]1([H])[C@@](C)([C@H]([C@@H](C2)O)O)CO)O)C
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Guavenoic acid Related Classifications
HY-N19830 Related Classifications
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