2. Metabolic Enzyme/Protease Apoptosis
  3. Stearoyl-CoA Desaturase (SCD) Apoptosis
  4. CVT-11127

CVT-11127  (Synonyms: GS-456332)

製品番号: HY-113638 純度: 99.94%
COA 取扱説明書 Technical Support

CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer.

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CVT-11127

CVT-11127 構造式

CAS 番号 : 1018674-83-3

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 282 在庫あり
Solution
10 mM * 1 mL in DMSO USD 282 在庫あり
Solid
1 mg $119 在庫あり
5 mg $250 在庫あり
10 mg $350 在庫あり
25 mg $600 在庫あり
50 mg $900 在庫あり
100 mg $1350 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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CVT-11127 関連抗体

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製品説明

CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer[1].

IC50 & Target

SCD[1]
Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
81 nM
Compound: 6a
Inhibition of Delta-9-desaturase in human HepG2 cells
Inhibition of Delta-9-desaturase in human HepG2 cells
[PMID: 19249203]
体外実験

CVT-11127 (1 µM, 48 h) shows antiproliferation activity in H460 cells[1].
CVT-11127 (1 µM, 48 h) decreases the the population of cells in S-phase by 75%[1].
CVT-11127 (1 µM, 48 h) induces apoposis in H460 cells[1].
CVT-11127 (1, 2 µM) inhibitors the SCD (stearoylCoA desaturase) activity in H460 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CVT-11127 関連抗体

Cell Proliferation Assay[1]

Cell Line: H460 cells
Concentration: 1 µM
Incubation Time: 48 h
Result: Showed antiproliferation activity.

Cell Cycle Analysis[1]

Cell Line: H460 cells
Concentration: 1 µM
Incubation Time: 48 h
Result: Decreased the the population of cells in S-phase by 75%.

Apoptosis Analysis[1]

Cell Line: H460 cells
Concentration: 1 µM
Incubation Time: 24 h
Result: Induced apoposis H460 cells.
分子量

512.39

分子式

C25H23Cl2N5O3
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 25 mg/mL (48.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9516 mL 9.7582 mL 19.5164 mL
5 mM 0.3903 mL 1.9516 mL 3.9033 mL
10 mM 0.1952 mL 0.9758 mL 1.9516 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

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濃度 （終了）

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体積 （終了）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9516 mL 9.7582 mL 19.5164 mL 48.7910 mL
5 mM 0.3903 mL 1.9516 mL 3.9033 mL 9.7582 mL
10 mM 0.1952 mL 0.9758 mL 1.9516 mL 4.8791 mL
15 mM 0.1301 mL 0.6505 mL 1.3011 mL 3.2527 mL
20 mM 0.0976 mL 0.4879 mL 0.9758 mL 2.4395 mL
25 mM 0.0781 mL 0.3903 mL 0.7807 mL 1.9516 mL
30 mM 0.0651 mL 0.3253 mL 0.6505 mL 1.6264 mL
40 mM 0.0488 mL 0.2440 mL 0.4879 mL 1.2198 mL
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CVT-11127 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CVT-111271018674-83-3GS-456332CVT11127CVT 11127GS456332GS 456332Stearoyl-CoA Desaturase (SCD)ApoptosisH460 cellsapoposisS-phaselung cancerantiproliferationmonounsaturated fatty acids (MUFA)Inhibitorinhibitorinhibit

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製品名:
CVT-11127
製品番号:
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