Art. -Nr.: HY-139840

GCPII-IN-1

Name: GCPII-IN-1
Brand: MedChemExpress
SKU: HY-139840
Price: 85.00 USD
Availability: InStock
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GCPII-IN-1 (Compound 2) is a GCPII (also known as PSMA) inhibitor with a K_i of 44.3 nM. GCPII-IN-1 can be used in the research of prostate cancer.

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Reinheit : 99.83%
CAS. Nr.: 1025796-32-0
Formel: C₁₂H₂₁N₃O₇
Molecular Weight:319.31

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

GCPII-IN-1 Chemical Structure

CAS. Nr.: 1025796-32-0

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

GCPII-IN-1 (Compound 2) is a GCPII (also known as PSMA) inhibitor with a K_i of 44.3 nM. GCPII-IN-1 can be used in the research of prostate cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	>100 μM Compound: DCL	Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 5 days by MTT assay Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 5 days by MTT assay	[PMID: 33822606]
HEK-293T	CC₅₀	>100 μM Compound: DCL	Cytotoxicity against HEK293T cells assessed as cell growth inhibition incubated for 5 days by MTT assay Cytotoxicity against HEK293T cells assessed as cell growth inhibition incubated for 5 days by MTT assay	[PMID: 33822606]
LNCaP	IC₅₀	1470 nM Compound: DCL	Inhibition of PSMA in human LNCAP cells using NAAG as substrate measured after 2 hrs by amplex red reagent based fluorescence assay Inhibition of PSMA in human LNCAP cells using NAAG as substrate measured after 2 hrs by amplex red reagent based fluorescence assay	[PMID: 31248772]
LNCaP	IC₅₀	498 nM Compound: 10	Inhibition of [131I]DCIT from PSMA in human LNCAP cells Inhibition of [131I]DCIT from PSMA in human LNCAP cells	[PMID: 19111054]
MCF7	CC₅₀	>100 μM Compound: DCL	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 5 days by MTT assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 5 days by MTT assay	[PMID: 33822606]
WI-38 VA13	CC₅₀	>100 μM Compound: DCL	Cytotoxicity against human VA13 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human VA13 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 31248772]
WI-38 VA13	CC₅₀	>100 μM Compound: DCL	Cytotoxicity against human WI-38 VA13 cells assessed as cell growth inhibition incubated for 5 days by MTT assay Cytotoxicity against human WI-38 VA13 cells assessed as cell growth inhibition incubated for 5 days by MTT assay	[PMID: 33822606]

In Vitro

GCPII-IN-1 (compound KUE) serves as a PSMA targeting vector to be conjugated with the zwitterionic metal chelators to generate probes for prostate cancer imaging applications^[2].
GCPII-IN-1 can be radiolabeled with F-18 to be a PET agent for prostate cancer imaging^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1025796-32-0
Appearance Solid
Molecular Weight 319.31
Formel C₁₂H₂₁N₃O₇
Color White to off-white
SMILES

NCCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (156.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1318 mL

15.6588 mL

31.3175 mL

5 mM

0.6264 mL

3.1318 mL

6.2635 mL

10 mM

0.3132 mL

1.5659 mL

3.1318 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Jan Tykvart, et al. Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery. Bioorg Med Chem. 2014 Aug 1;22(15):4099-108. [Content Brief]

[2]. John V. Frangioni, et al. Zwitterionic metal chelators. US20250082792A1. 2025-10-14.

[3]. Mukesh K. Pandey, et al. Platform approach f-18 radiolabeling of various peptides in aqueous medium. WO2025054616A1. 2025-03-13.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1318 mL	15.6588 mL	31.3175 mL	78.2938 mL
	5 mM	0.6264 mL	3.1318 mL	6.2635 mL	15.6588 mL
	10 mM	0.3132 mL	1.5659 mL	3.1318 mL	7.8294 mL
	15 mM	0.2088 mL	1.0439 mL	2.0878 mL	5.2196 mL
	20 mM	0.1566 mL	0.7829 mL	1.5659 mL	3.9147 mL
	25 mM	0.1253 mL	0.6264 mL	1.2527 mL	3.1318 mL
	30 mM	0.1044 mL	0.5220 mL	1.0439 mL	2.6098 mL
	40 mM	0.0783 mL	0.3915 mL	0.7829 mL	1.9573 mL
	50 mM	0.0626 mL	0.3132 mL	0.6264 mL	1.5659 mL
	60 mM	0.0522 mL	0.2610 mL	0.5220 mL	1.3049 mL
	80 mM	0.0391 mL	0.1957 mL	0.3915 mL	0.9787 mL
	100 mM	0.0313 mL	0.1566 mL	0.3132 mL	0.7829 mL

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GCPII-IN-1