NEK4 - NIMA related kinase 4 Gene

Also Known as NRK2; STK2; pp12301

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6787

About NEK4

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,708,444-52,770,940 (from NCBI)

This gene has 7 transcripts (splice variants), 204 orthologues and 35 paralogues. Broad expression in testis (RPKM 13.9), thyroid (RPKM 5.5) and 25 other tissues.

Summary

The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]

NEK4 Products (5)

mRNA Protein Name
NM_001193533.3 NP_001180462.1 serine/threonine-protein kinase Nek4 isoform 2
NM_001348412.2 NP_001335341.1 serine/threonine-protein kinase Nek4 isoform 3
NM_001348413.2 NP_001335342.1 serine/threonine-protein kinase Nek4 isoform 4
NM_001348414.2 NP_001335343.1 serine/threonine-protein kinase Nek4 isoform 5
NM_003157.6 NP_003148.2 serine/threonine-protein kinase Nek4 isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence Verweise Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
22851694 GOA
involved in mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
22851694 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
22851694 GOA
involved in regulation of cellular senescence IMP
IMP: Inferred from mutant phenotype
22851694 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEK4 Protein Structure

Pkinase

Pkinase: Protein kinase domain (7 - 261)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 841 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Nek4

  • NIMA (never in mitosis gene a)-related kinase 4

NEK4 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P81613 NEK4 Antibody (YA1358) WB Human
HY-P81613A NEK4 Antibody (YA1358)(PBS only) WB Human

Related Diseases

Diseases Alias
Ciliopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-183068 AP4-43 Inhibitor 99.76% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NEK4 RGD RGD:1304995
Felis catus NEK4 VGNC VGNC:80635
Canis familiaris NEK4 VGNC VGNC:43732
Macaca mulatta NEK4 VGNC VGNC:81483
Bos taurus NEK4 VGNC VGNC:31995
Mus musculus NEK4 MGD MGI:1344404
Others NEK4 NCBI