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Art. -Nr.: HY-163755

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GPER activator 1

GPER activator 1 (compound 6-26) is a GPER-selective compound without cytotoxicity. GPER activator 1 exhibits dual inhibition of TNFα- and IL-6-induced inflammation.

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CAS. Nr.: 2629960-35-4
Formel: C₁₇H₁₄ClFN₂O₂S
Molecular Weight:364.82

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

GPER activator 1 Chemical Structure

CAS. Nr.: 2629960-35-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

GPER activator 1 (compound 6-26) is a GPER-selective compound without cytotoxicity. GPER activator 1 exhibits dual inhibition of TNFα- and IL-6-induced inflammation^[1].

Alle Estrogen Receptor/ERR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
U-937	IC₅₀	0.23 μM Compound: 6-26	Inhibition of TNFalpha induced adhesion of TPA treated human U-937 cells to human HT-29 cells pretreated with HT-29 for 1 hr followed by U-937 addition along with TNFalpha stimulation for 3 hrs by fluorescence based microplate reader assay Inhibition of TNFalpha induced adhesion of TPA treated human U-937 cells to human HT-29 cells pretreated with HT-29 for 1 hr followed by U-937 addition along with TNFalpha stimulation for 3 hrs by fluorescence based microplate reader assay	[PMID: 38896548]
U-937	IC₅₀	0.35 μM Compound: 6-26	Inhibition of IL6 induced adhesion of TPA treated human U-937 cells to human HT-29 cells pretreated with HT-29 for 1 hr followed by U-937 addition along with IL6 stimulation for 3 hrs by fluorescence based microplate reader assay Inhibition of IL6 induced adhesion of TPA treated human U-937 cells to human HT-29 cells pretreated with HT-29 for 1 hr followed by U-937 addition along with IL6 stimulation for 3 hrs by fluorescence based microplate reader assay	[PMID: 38896548]

Chemical Information

CAS. Nr. 2629960-35-4
Molecular Weight 364.82
Formel C₁₇H₁₄ClFN₂O₂S
SMILES

CC1=C(C(C)=C(C(NC(C2=C(C3=C(S2)C=C(F)C=C3)Cl)=O)=N1)C)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Bhuwan Prasad Awasthi, et al. G Protein-Coupled Estrogen Receptor-Mediated Anti-Inflammatory and Mucosal Healing Activity of a Trimethylpyridinol Analogue in Inflammatory Bowel Disease. J Med Chem.2024 Jul 11;67(13):10601-10621. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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