HEBP2 - heme binding protein 2 Gene

Also Known as PP23; SOUL; C6orf34; C6ORF34B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23593

About HEBP2

Cytogenetic location: 6q24.1 Genomic coordinates (GRCh38): 6:138,403,531-138,422,197 (from NCBI)

This gene has 4 transcripts (splice variants), 175 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 80.4), prostate (RPKM 27.2) and 22 other tissues.

Summary

The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016]

HEBP2 Products (3)

mRNA Protein Name
NM_001326380.2 NP_001313309.1 heme-binding protein 2 isoform 1
NM_001326381.2 NP_001313310.1 heme-binding protein 2 isoform 3
NM_014320.3 NP_055135.1 heme-binding protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17098234 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
17098234 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HEBP2 Protein Structure

SOUL

SOUL: SOUL heme-binding protein (20 - 195)

  • 0
  • 100
  • 205 a.a.
Protein Preferred Names Protein Names

heme-binding protein 2

  • placental protein 23

HEBP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HEBP2 Q9Y5Z4 PDCD6 Homo sapiens O75340
Y2H Prey Pooling
25416956
Intra
HEBP2 Q9Y5Z4 PDCD6 Homo sapiens O75340
Y2H Prey Pooling
32296183
Intra
HEBP2 Q9Y5Z4 PDCD6 Homo sapiens O75340
MAPPIT
32296183
Intra
HEBP2 Q9Y5Z4 PDCD6 Homo sapiens O75340
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06105 HEBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HEBP2 VGNC VGNC:73172
Mus musculus HEBP2 MGD MGI:1860084
Canis familiaris HEBP2 VGNC VGNC:41640
Felis catus HEBP2 VGNC VGNC:102437
Bos taurus HEBP2 VGNC VGNC:29798
Rattus norvegicus HEBP2 RGD RGD:1311553
Others HEBP2 NCBI