CCNB2 - cyclin B2 Gene

Also Known as HsT17299

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9133

About CCNB2

Cytogenetic location: 15q22.2 Genomic coordinates (GRCh38): 15:59,105,146-59,125,045 (from NCBI)

This gene has 5 transcripts (splice variants), 241 orthologues and 18 paralogues. Biased expression in testis (RPKM 42.1), bone marrow (RPKM 26.8) and 11 other tissues.

Summary

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]

CCNB2 Products (1)

mRNA Protein Name
NM_004701.4 NP_004692.1 G2/mitotic-specific cyclin-B2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15232106 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNB2 Protein Structure

Cyclin_N

Cyclin_N: Cyclin, N-terminal domain (137 - 261)

Cyclin_C

Cyclin_C: Cyclin, C-terminal domain (264 - 381)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
Protein Preferred Names Protein Names

G2/mitotic-specific cyclin-B2

CCNB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CCNB2 O95067 FLNA Homo sapiens P21333
Anti Bait CoIP
17408621
Intra
CCNB2 O95067 CDK2 Homo sapiens P24941
GMS
24358021
Cross: Cross-species interaction Intra: Intraspecies interaction

CCNB2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80998 Cyclin B2 Antibody (YA4635) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Anauxetic Dysplasia 1

  • Anauxetic Dysplasia

  • Spondylometaepiphyseal Dysplasia, Menger Type

  • Spondylometaepiphyseal Dysplasia, Anauxetic Type

  • Spondyloepimetaphyseal Dysplasia, Anauxetic Type

  • ANXD1

  • Anxd

  • Spondylometaepiphyseal Dysplasia Anauxetic Type

  • Spondylometaepiphyseal Dysplasia Menger Type

  • Ad

  • Spondyloepimetaphyseal Dysplasia, Menger Type

  • Dysplasia, Anauxetic, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS21505 Ccnb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02120 CCNB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28023 Ccnb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CCNB2 VGNC VGNC:60553
Canis familiaris CCNB2 VGNC VGNC:103665
Rattus norvegicus CCNB2 RGD RGD:1308176
Bos taurus CCNB2 VGNC VGNC:26960
Macaca mulatta CCNB2 VGNC VGNC:70721
Mus musculus CCNB2 MGD MGI:88311
Others CCNB2 NCBI