2. Apoptosis
  3. Apoptosis
  4. Dehydroeffusol

Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. It shows very low toxicity.

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Dehydroeffusol

Dehydroeffusol 構造式

CAS 番号 : 137319-34-7

容量 価格（税別） 在庫状況 数量
5 mg $280 在庫あり
10 mg $480 在庫あり
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100 mg   お問い合わせ  

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Dehydroeffusol 関連抗体

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製品説明

Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. It shows very low toxicity[1][2].

Cellular Effect
Cell Line Type Value Description References
AGS IC50
32.9 μM
Compound: Dehydroeffusol
Antiproliferative activity against human AGS cells assessed as reduction in cell viability after 48 hrs by Alamar Blue assay
Antiproliferative activity against human AGS cells assessed as reduction in cell viability after 48 hrs by Alamar Blue assay
[PMID: 33064469]
RAW264.7 IC50
10.5 μM
Compound: dehydroeffusol
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced nitric oxide production
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced nitric oxide production
[PMID: 29280630]
RAW264.7 IC50
12.7 μM
Compound: dehydroeffusol
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced nitric oxide production
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced nitric oxide production
[PMID: 29280630]
SGC-7901 IC50
35.9 μM
Compound: Dehydroeffusol
Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue assay
Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue assay
[PMID: 33064469]
体外実験

Dehydroeffusol suppresses the expression of vasculogenic mimicry key gene VE-cadherin[2].
Dehydroeffusol decreases the MMP2 expression and activity in gastric cancer cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dehydroeffusol 関連抗体
分子量

250.29

分子式

C17H14O2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C2C3=C(C=C)C=C(O)C=C3C=CC2=C1C
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (399.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9954 mL 19.9768 mL 39.9537 mL
5 mM 0.7991 mL 3.9954 mL 7.9907 mL
10 mM 0.3995 mL 1.9977 mL 3.9954 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (9.99 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (9.99 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9954 mL 19.9768 mL 39.9537 mL 99.8841 mL
5 mM 0.7991 mL 3.9954 mL 7.9907 mL 19.9768 mL
10 mM 0.3995 mL 1.9977 mL 3.9954 mL 9.9884 mL
15 mM 0.2664 mL 1.3318 mL 2.6636 mL 6.6589 mL
20 mM 0.1998 mL 0.9988 mL 1.9977 mL 4.9942 mL
25 mM 0.1598 mL 0.7991 mL 1.5981 mL 3.9954 mL
30 mM 0.1332 mL 0.6659 mL 1.3318 mL 3.3295 mL
40 mM 0.0999 mL 0.4994 mL 0.9988 mL 2.4971 mL
50 mM 0.0799 mL 0.3995 mL 0.7991 mL 1.9977 mL
60 mM 0.0666 mL 0.3329 mL 0.6659 mL 1.6647 mL
80 mM 0.0499 mL 0.2497 mL 0.4994 mL 1.2486 mL
100 mM 0.0400 mL 0.1998 mL 0.3995 mL 0.9988 mL
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Dehydroeffusol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dehydroeffusol137319-34-7ApoptosisInhibitorinhibitorinhibit

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製品名:
Dehydroeffusol
製品番号:
HY-N5058
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