Complement factor D
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.21 Serine endopeptidases > 3.4.21.46 complement factor D
Complement factor D (adipsin) is the alternative-pathway serine protease in family S1, analogous to C1s cleavage of C2, which selectively cleaves the Arg-Lys bond in factor B when B is in complex with C3b or cobra-venom factor, forming the alternative-pathway C3 convertase C3bBb. By activating factor B it drives alternative-pathway complement activation. It appears in viruses and cellular organisms.
Complement factor D (adipsin) is the alternative-pathway serine protease in family S1, analogous to C1s cleavage of C2, which selectively cleaves the Arg-Lys bond in factor B when B is in complex with C3b or cobra-venom factor, forming the alternative-pathway C3 convertase C3bBb. By activating factor B it drives alternative-pathway complement activation. It appears in viruses and cellular organisms.
References:
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