Fas - Fas (TNF receptor superfamily member 6) Gene

Also Known as lpr; APO1; APT1; CD95; TNFR6; Tnfrsf6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14102

Summary

Enables identical protein binding activity. Involved in positive regulation of protein-containing complex assembly. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway; hematopoietic or lymphoid organ development; and regulation of hemopoiesis. Located in external side of plasma membrane and extracellular region. Part of CD95 death-inducing signaling complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Sjogren's syndrome; autoimmune lymphoproliferative syndrome; systemic lupus erythematosus; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic Cancer (multiple); pre-eclampsia (multiple); and urinary system Cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor). [provided by Alliance of Genome Resources, Apr 2022]

Fas Products (2)

mRNA Protein Name
NM_001146708.1 NP_001140180.1 tumor necrosis factor receptor superfamily member 6 isoform 2 precursor
NM_007987.2 NP_032013.2 tumor necrosis factor receptor superfamily member 6 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
8524870 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7536190 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell mediated immunity IMP
IMP: Inferred from mutant phenotype
18199416 MGI
acts upstream of or within T cell homeostasis IMP
IMP: Inferred from mutant phenotype
8640868 MGI
acts upstream of or within activation-induced cell death of T cells IDA
IDA: Inferred from direct assay
12702495 MGI
acts upstream of or within activation-induced cell death of T cells IMP
IMP: Inferred from mutant phenotype
7602121 MGI
acts upstream of or within apoptotic process IMP
IMP: Inferred from mutant phenotype
8700551 MGI
acts upstream of or within apoptotic signaling pathway IDA
IDA: Inferred from direct assay
7511063 MGI
acts upstream of or within cellular response to lithium ion IMP
IMP: Inferred from mutant phenotype
20530871 MGI
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
23785138 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
17980593 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
12011074 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
13679421 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: Inferred from direct assay
8524870 MGI
involved in extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: Inferred from direct assay
10950869 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IGI
IGI: Inferred from genetic interaction
12431371 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: Inferred from mutant phenotype
8524870 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
7602121 MGI
acts upstream of or within hepatocyte apoptotic process IGI
IGI: Inferred from genetic interaction
20436477 MGI
acts upstream of or within immunoglobulin production IMP
IMP: Inferred from mutant phenotype
18199416 MGI
acts upstream of or within inflammatory cell apoptotic process IDA
IDA: Inferred from direct assay
12801066 MGI
acts upstream of or within inflammatory cell apoptotic process IMP
IMP: Inferred from mutant phenotype
12801066 MGI
acts upstream of or within lymphocyte apoptotic process IDA
IDA: Inferred from direct assay
15632112 MGI
acts upstream of or within motor neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
13679421 MGI
acts upstream of or within necroptotic signaling pathway IGI
IGI: Inferred from genetic interaction
21052097 MGI
acts upstream of or within negative regulation of B cell activation IMP
IMP: Inferred from mutant phenotype
6610701 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
7595210 MGI
acts upstream of or within negative thymic T cell selection IMP
IMP: Inferred from mutant phenotype
10429671 MGI
acts upstream of or within neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
20530871 MGI
involved in positive regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
10950869 MGI
acts upstream of or within regulation of B cell differentiation IMP
IMP: Inferred from mutant phenotype
6610701 MGI
acts upstream of or within regulation of T cell differentiation IMP
IMP: Inferred from mutant phenotype
6610701 MGI
acts upstream of or within regulation of hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
9697835 MGI
acts upstream of or within regulation of myeloid cell differentiation IMP
IMP: Inferred from mutant phenotype
9697835 MGI
acts upstream of or within response to glucocorticoid IMP
IMP: Inferred from mutant phenotype
7602121 MGI
acts upstream of or within response to toxic substance IMP
IMP: Inferred from mutant phenotype
8557033 MGI
acts upstream of or within spleen development IMP
IMP: Inferred from mutant phenotype
18199416 MGI
Cellular Component GO Annotation Evidence References Source
part of CD95 death-inducing signaling complex IDA
IDA: Inferred from direct assay
20935634 MGI
located in cell surface IDA
IDA: Inferred from direct assay
7595210 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
8788039 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
7595210 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 6

  • FASLG receptor

  • Fas (TNF receptor superfamily member)

  • Fas antigen

  • apo-1 antigen

  • apoptosis-mediating surface antigen FAS

  • lymphoproliferation

Recombinant Fas Proteins

Cat. No. Product Name Accession Purity
HY-P70330 Fas/CD95 Protein, Mouse (HEK293, His) P25446 (Q22-R169) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78296 Fas/CD95 Protein, Mouse (HEK293, Fc) P25446 (Q22-R169) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0515 Ibandronate Sodium Monohydrate Inducer 99.89% Unkown
HY-B0515B Ibandronate Sodium Inducer 99.89% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13721 Phenoxodiol 99.89% Phase 3

Pre-clinical Phase

Bioactive Molecules (59)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150190 F5446 99.73% Unkown
HY-P10102 Kp7-6 99.28% Unkown
HY-103243 TCPOBOP Inhibitor 99.70% Unkown
HY-14414 GSK4112 Inhibitor 99.87% Unkown
HY-12325 GSK2194069 Inhibitor 99.80% Unkown
HY-16100 BI 99179 Inhibitor 99.38% Unkown
HY-N0704 Agrimol B 99.75% Unkown
HY-112716 N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 99.0% Unkown
HY-133897 (Rac)-Indoximod 99.60% Unkown
HY-P10227 Xelafaslatide Inhibitor 99.88% Unkown
HY-101849 Fasentin 98.0% Unkown
HY-N2116 Ginkgolic acid C17:1 99.80% Unkown
HY-N0686 Pseudoprotodioscin Inhibitor 99.17% Unkown
HY-100755 KR-33493 Inhibitor 99.94% Unkown
HY-21088 3-Amino-2-piperidinone 99.93% Unkown
HY-N4177 Rubrofusarin gentiobioside Inhibitor 99.07% Unkown
HY-Y0598 trans-Chalcone 99.25% Unkown
HY-129624A Bisindolylmaleimide VIII acetate 99.68% Unkown
HY-P6440 Met-12 Inhibitor 99.66% Unkown
HY-122394 Thiolactomycin Inhibitor ≥97.0% Unkown
HY-160912 ELOVL6-IN-5 Inhibitor 95.47% Unkown
HY-N6777 Penicillic acid Inhibitor 99.83% Unkown
HY-103347 M50054 Inhibitor 98.44% Unkown
HY-113963 Ac-​IETD-​CHO Inhibitor 98.59% Unkown
HY-103348 Boc-Asp(OMe)-fluoromethyl ketone Inhibitor 98.0% Unkown
HY-N3011 Iridin 99.72% Unkown
HY-N7930 Crenulatin 99.85% Unkown
HY-N12717 Casuarinin 98.24% Unkown
HY-N0853A Alisol A 24-acetate 98.0% Unkown
HY-108610C (S)-Edelfosine Inducer 99.90% Unkown
HY-N12378 β-Patchoulene 96.88% Unkown
HY-P10815 IP3RCYT Inhibitor 95.87% Unkown
HY-RS04753 FASN Human Pre-designed siRNA Set A / Unkown
HY-RS04754 Fasn Mouse Pre-designed siRNA Set A / Unkown
HY-N7521 Procyanidin C2 / Unkown
HY-111165 SNX-7081 / Unkown
HY-103323 Fas C-Terminal Tripeptide Inhibitor / Unkown
HY-118147 ML356 Inhibitor / Unkown
HY-146197 Apoptotic agent-1 Inducer / Unkown
HY-167879 (Rac)-NPD6433 Inhibitor / Unkown
HY-168877 FMP Activator / Unkown
HY-174133 HSD17B13-IN-104 Inhibitor 95.0% Unkown
HY-175057 Ac-IETD-CHO TFA Inhibitor / Unkown
HY-184685 Antimycobacterial agent-18 Inhibitor / Unkown
HY-N6777S Penicillic acid-13C8 / Unkown
HY-P3779 Amyloid 17-42 Inducer / Unkown
HY-P5797 Fasciculin-II Inhibitor / Unkown
HY-P5798 Fasciculin-I Inhibitor / Unkown
HY-RS04751 FAS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-129624 Bisindolylmaleimide VIII / Unkown
HY-167879A NPD6433 Inhibitor / Unkown
HY-168770 Cl-Necrostatin-1 Inhibitor / Unkown
HY-174713 Human FASLG mRNA / Unkown
HY-174714 Human FAS mRNA / Unkown
HY-N10612 Petasin / Unkown
HY-N5134A ara-GMP / Unkown
HY-P10401 TAT-GluR6-9c Antagonist / Unkown
HY-RS16712 Fas Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23147 Fas Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99133 Anti-Mouse Fas Ligand Antibody (MFL3) Inhibitor / Unkown
HY-P991606 TRX585 / Unkown
HY-P992072 Anti-Human/Mouse CD95 Antibody (HFE7A) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fas NCBI NCBI:355