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KR-33493 

Cat. No.: HY-100755 Purity: 99.82%
Handling Instructions

KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1).

For research use only. We do not sell to patients.

KR-33493 Chemical Structure

KR-33493 Chemical Structure

CAS No. : 1021497-97-1

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 101 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
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10 mg USD 150 In-stock
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25 mg USD 250 In-stock
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50 mg USD 450 In-stock
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100 mg USD 700 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1).

IC50 & Target

FAF1[1]

In Vivo

Body weight changes of both sexes are not related to KR-33493 in all doses. In rats administrated KR-33493 for 4 weeks, no test article-related changes in any treated groups of either sex are found in hematology, serum biochemistry, and urinalysis. In dogs administrated KR-33493 for 2 weeks, red blood cell count (RBC) value in males is significantly higher at the 1000 mg/kg/day dose than that of the control group (i.e., 6.96±0.323 vs. 6.12±0.418). However, the change of RBC is recovered after the end of the administration period. The dose-normalized AUClast is not significantly different between the groups, suggesting that KR-33493 is governed by linear kinetics[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

460.34

Formula

C₂₀H₁₈BrN₃O₃S

CAS No.

1021497-97-1

SMILES

OC(C1=NN(CCC2=CC=CC=C2)C=C1NC(CSC3=CC=C(Br)C=C3)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (67.34 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1723 mL 10.8615 mL 21.7231 mL
5 mM 0.4345 mL 2.1723 mL 4.3446 mL
10 mM 0.2172 mL 1.0862 mL 2.1723 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.43 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.43 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

A total of 93 male and 93 female specific pathogen-free rats (6 weeks of age), and 16 male and 16 female beagle dogs (8 months of age) are used in this study. In a toxicokinetic study, rat blood samples (approximately 0.6 mL) are collected into tubes containing heparin from the lateral tail vein at 0, 0.5, 1, 2, 4, 8, 12, and 24 h after dosing with KR-33493 at doses of 50, 150, and 500 mg/kg/day on Day 1 and Week 4. Dog blood samples (approximately 0.6 mL) are collected into tubes containing EDTA-2K from the cephalic vein at 0, 0.5, 1, 2, 4, 6, 8, and 24 h after dosing at KR-33493 doses of 50, 250, and 1000 mg/kg/day on Day 1 and Week 2. The plasma is separated by centrifugation (approximately 132,000 g, 3 min, 4°C) and stored at approximately -80°C until analysis. The KR-33493 concentration in plasma is quantified[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

KR-33493KR33493KR 33493OthersInhibitorinhibitorinhibit

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Product Name:
KR-33493
Cat. No.:
HY-100755
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