2. Protein Tyrosine Kinase/RTK
  3. DYRK
  4. Dyrk1A-IN-2

Dyrk1A-IN-2 (Compound 63) is a DYRK1A inhibitor with an EC50 of 37 nM. Dyrk1A-IN-2 exhibits highly potent human β-cell replication-promoting activity and low cytotoxicity.

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Dyrk1A-IN-2

Dyrk1A-IN-2 화학구조

CAS No. : 2459657-37-3

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Dyrk1A-IN-2 Related Antibodies

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DYRK1 DYRK2 DYRK3 DYRK4 HIPK PRP4

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제품 설명

Dyrk1A-IN-2 (Compound 63) is a DYRK1A inhibitor with an EC50 of 37 nM. Dyrk1A-IN-2 exhibits highly potent human β-cell replication-promoting activity and low cytotoxicity[1].

IC50 & Target

DYRK1A

37 nM (EC50)

Cellular Effect
Cell Line Type Value Description References
HEK-293T CC50
2962 nM
Compound: 63
Cytotoxicity against human HEK293T cells transfected with DYRK1A co-tranfected with Renilla plasmid, pGL3-NFAT and NFATc1 assessed as reduction in luciferase activity by measuring cell number
Cytotoxicity against human HEK293T cells transfected with DYRK1A co-tranfected with Renilla plasmid, pGL3-NFAT and NFATc1 assessed as reduction in luciferase activity by measuring cell number
[PMID: 31757680]
HEK-293T EC50
37 nM
Compound: 63
Inhibition of human DYRK1A transfected in HEK293T cells co-transfected with Renilla plasmid, pGL3-NFAT and NFATc1 assessed as derepression of NFAT-dependent luciferase activity measured after 48 hrs by luciferase assay
Inhibition of human DYRK1A transfected in HEK293T cells co-transfected with Renilla plasmid, pGL3-NFAT and NFATc1 assessed as derepression of NFAT-dependent luciferase activity measured after 48 hrs by luciferase assay
[PMID: 31757680]
분자량

490.60

화학식

C27H34N6O3
CAS No.
SMILES

CCOC(C1=C(C2=NC(C3=CC(N)=NC=C3)=CC=C2N=C1)N[C@@H]4CC[C@H](CC4)CN5CCOCC5)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Dyrk1A-IN-2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dyrk1A-IN-22459657-37-3DYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinasediabetesInhibitorinhibitorinhibit

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상품명:
Dyrk1A-IN-2
Cat. No.:
HY-147760
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