Cyprolidol
Cyprolidol is an orally active inhibitor of acetylcholine receptor and histamine receptor with potential antidepressant activity. Cyprolidol inhibits acetylcholine-induced hypotensive response, histamine-induced systolic blood pressure decrease, tyramine-induced systolic blood pressure increase, serotonin-induced systolic blood pressure response in anesthetized animals, and bretylium-induced systolic blood pressure increase in anesthetized cats. Cyprolidol potentiates norepinephrine-induced systolic blood pressure increase, slightly potentiates epinephrine-induced systolic blood pressure increase, and enhances the anesthetic depth of barbiturates. Cyprolidol can be used in the research of depression.
For research use only. We do not sell to patients.
- CAS No.: 4904-00-1
- Formula: C21H19NO
- Molecular Weight:301.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Histamine Receptor Isoforms
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Biological Activity
Cyprolidol (10 mg/kg; i.v.; single dose) produces a mean -34.16 mmHg systolic pressure fall in anesthetized dogs, while also potentiating norepinephrine and epinephrine pressor responses and inhibiting tyramine, histamine, acetylcholine, and serotonin responses[1].
Cyprolidol (10-30 mg/kg; i.v.; single dose) produces a biphasic systolic pressure response (-34.00 mmHg fall followed by +38.00 mmHg rise) in anesthetized cats, while also potentiating norepinephrine and epinephrine pressor responses, inhibiting tyramine, histamine, acetylcholine, serotonin, and bretylium responses, and at 30 mg/kg i.v. reversing bretylium-induced pressure rises to falls[1].
Cyprolidol (30 mg/kg; p.o.; daily; 14 days) does not alter normotensive systolic pressure in conscious dogs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4904-00-1
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Molecular Weight 301.38
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Formula C21H19NO
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SMILES
OC(C1=CC=CC=C1)(C2=CC=CC=C2)[C@H]3[C@H](C4=CC=NC=C4)C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)