NFKB2 - nuclear factor kappa B subunit 2 Gene

Also Known as p52; p100; H2TF1; LYT10; CVID10; LYT-10; NF-kB2; p49/p100

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4791

About NFKB2

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,394,110-102,402,529 (from NCBI)

This gene has 20 transcripts (splice variants), 125 orthologues, 4 paralogues and is associated with 58 phenotypes. Ubiquitous expression in appendix (RPKM 21.5), bone marrow (RPKM 20.6) and 25 other tissues.

Summary

This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

NFKB2 Products (6)

mRNA	Protein	Name
NM_001077494.3	NP_001070962.1	nuclear factor NF-kappa-B p100 subunit isoform a
NM_001322935.1	NP_001309864.1	nuclear factor NF-kappa-B p100 subunit isoform c
NM_001322934.2	NP_001309863.1	nuclear factor NF-kappa-B p100 subunit isoform a
NM_002502.6	NP_002493.3	nuclear factor NF-kappa-B p100 subunit isoform b
NM_001261403.3	NP_001248332.1	nuclear factor NF-kappa-B p100 subunit isoform b
NM_001288724.1	NP_001275653.1	nuclear factor NF-kappa-B p100 subunit isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12835724	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12835724	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8441377	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	37816088	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12835724	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8360178	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Bcl3/NF-kappaB2 complex	IDA IDA: Inferred from direct assay	9407099	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15677444	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15677444	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFKB2 Protein Structure

RHD_DNA_bind

Ank

Ank_2

Death

0
200
400
600
800
900 a.a.

Protein Preferred Names	Protein Names
nuclear factor NF-kappa-B p100 subunit	DNA-binding factor KBF2 NFKB, p52/p100 subunit lymphocyte translocation chromosome 10 protein nuclear factor Kappa-B, subunit 2 nuclear factor NF-kappa-B p52 subunit nuclear factor of Kappa light chain gene enhancer in B cells 2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) oncogene Lyt-10 transcription factor NFKB2

NFKB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NFKB2	Q00653	NFKB1	Homo sapiens	P19838	Y2H	21988832
Intra	NFKB2	Q00653	NFKB1	Homo sapiens	P19838	Anti Tag CoIP	35271311
Intra	NFKB2	Q00653	REL	Homo sapiens	Q04864	TAP	14743216
Intra	NFKB2	Q00653	REL	Homo sapiens	Q04864	Anti Tag CoIP	35271311
Intra	NFKB2	Q00653	NFKBIA	Homo sapiens	P25963	Anti Tag CoIP	35271311
Intra	NFKB2	Q00653	NFKBIA	Homo sapiens	P25963	TAP	14743216
Intra	NFKB2	Q00653	NFKBIB	Homo sapiens	Q15653	TAP	14743216
Intra	NFKB2	Q00653	MAP3K8	Homo sapiens	P41279	TAP	14743216
Intra	NFKB2	Q00653	RELB	Homo sapiens	Q01201	Anti Tag CoIP	35271311
Intra	NFKB2	Q00653	RELB	Homo sapiens	Q01201	TAP	14743216
Intra	NFKB2	Q00653	SUMO1	Homo sapiens	P63165	Anti Bait CoIP	18617892

Cross: Cross-species interaction Intra: Intraspecies interaction

NFKB2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80763	NF-KB p100 Antibody (YA269)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P80763A	NF-KB p100 Antibody (YA269)(PBS only)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P84451	NF-KB p100 Antibody (YA4148)	WB, ELISA	Human, Mouse
HY-P84451A	NF-KB p100 Antibody (YA4148)(PBS only)	WB, ELISA	Human, Mouse
HY-P86235	NF-KB p100 Antibody (YA5927)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Immunodeficiency, Common Variable, 10	CVID10 Deficit In Anterior Pituitary Function And Variable Immunodeficiency David Immunodeficiency, Common Variable, With Central Adrenal Insufficiency Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome David Syndrome Common Variable Immunodeficiency With Central Adrenal Insufficiency Immunodeficiency, Variable, Common, Type 10
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
B-Cell Non-Hodgkin Lymphoma	B-Cell Nhl B-Cell Non-Hodgkins Lymphoma
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Acth Deficiency, Isolated	Adrenocorticotropic Hormone Deficiency IAD Congenital Isolated Acth Deficiency Isolated Acth Deficiency Isolated Adrenocorticotropic Hormone Deficiency Adrenocorticotropic Hormone Deficiency Adrenocorticotropic Hormone [Acth] Deficiency Secondary Adrenocortical Insufficiency
Immunodeficiency, Common Variable, 1	CVID1 Antibody Deficiency Due To Icos Defect Icos Deficiency Immunodeficiency, Variable, Common, Type 1
Incontinentia Pigmenti	Bloch-Sulzberger Syndrome IP Incontinentia Pigmenti, Familial Male-Lethal Type Incontinentia Pigmenti Syndrome Bloch-Siemens Syndrome Ip2 Incontinentia Pigmenti, Type Ii, Formerly Ip2, Formerly Incontinentia Pigmenti Type 2 Bloch-Siemens-Sulzberger Syndrome Familial Incontinentia Pigmenti Male-Lethal Type Familial Incontinentia Pigmenti Type Ii Incontinentia Pigmenti, Type Ii Bloch Sulzberger Syndrome Incontinentia Pigmenti Achromians Incontinentia Pigmenti Of Bloch-Sulzberger Nevus Pigmentosus Systematicus
Osteopetrosis	Albers-Schonberg Disease Marble Bone Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Transient Hypogammaglobulinemia Of Infancy	Immunoglobulin Maturational Delay Thi - [Transient Hypogammaglobulinaemia Of Infancy]
Asbestos-Related Lung Carcinoma
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Acquired Hypogammaglobulinemia Common Variable Immune Deficiency Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-A0024	Tolterodine	98.61%	Yes
HY-90010	Tolterodine tartrate	98.64%	Yes
HY-90010R	Tolterodine tartrate (Standard)	/	Unkown

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3229	SN52	Inhibitor	99.31%	Unkown
HY-149351	NF-κB-IN-10	Inhibitor	/	Unkown
HY-A0024S	Tolterodine-d14 hydrochloride	Substrate	99.0%	Unkown
HY-RS09257	NFKB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09258	Nfkb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09259	Nfkb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174568	Human NFKB2 mRNA		/	Unkown
HY-90010S	Tolterodine tartrate-d14		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NFKB2	RGD	RGD:1307189
Felis catus	NFKB2	VGNC	VGNC:68482
Mus musculus	NFKB2	MGD	MGI:1099800
Bos taurus	NFKB2	VGNC	VGNC:32044
Canis familiaris	NFKB2	VGNC	VGNC:43781
Others	NFKB2	NCBI