CDK10 - cyclin dependent kinase 10 Gene

Also Known as ALSAS; PISSLRE

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8558

About CDK10

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:89,686,689-89,696,354 (from NCBI)

This gene has 22 transcripts (splice variants), 200 orthologues, 26 paralogues and is associated with 3 phenotypes. Ubiquitous expression in duodenum (RPKM 16.8), thyroid (RPKM 15.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

CDK10 Products (4)

mRNA	Protein	Name
NM_001098533.3	NP_001092003.2	cyclin-dependent kinase 10 isoform c
NM_001160367.2	NP_001153839.1	cyclin-dependent kinase 10 isoform d
NM_052987.4	NP_443713.2	cyclin-dependent kinase 10 isoform b
NM_052988.5	NP_443714.3	cyclin-dependent kinase 10 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18242510	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	27104747	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	27104747	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	27104747	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	27104747	GOA
involved in regulation of cell cycle G2/M phase transition	IDA IDA: Inferred from direct assay	7664269	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in ciliary basal body	IDA IDA: Inferred from direct assay	27104747	GOA
part of cyclin-dependent protein kinase holoenzyme complex	IPI IPI: Inferred from physical interaction	24218572	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11006117	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK10 Protein Structure

Pkinase

0
100
200
300
360 a.a.

Protein Preferred Names	Protein Names
cyclin-dependent kinase 10	CDC2-related protein kinase

CDK10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDK10	Q15131	HSPA8	Homo sapiens	P11142	Anti Tag CoIP	33961781
Intra	CDK10	Q15131	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	CDK10	Q15131	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	CDK10	Q15131	PIN1	Homo sapiens	Q13526	Anti Bait CoIP	22158035
Intra	CDK10	Q15131	PIN1	Homo sapiens	Q13526	Anti Tag CoIP	22158035

Cross: Cross-species interaction Intra: Intraspecies interaction

CDK10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810741	CDK10 Antibody (YA9984)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Al Kaissi Syndrome	ALKAS Growth Retardation, Spine Malformation, Dysmorphic Facies, And Developmental Delay
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations	Star Syndrome Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome Syndactyly With Renal And Anogenital Malformations STAR Syndactyly, Telecanthus, Anogenital And Renal Malformations Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Acromesomelic Dysplasia 2b	Fibular Hypoplasia And Complex Brachydactyly Du Pan Syndrome AMD2B Dupans Acromesomelic Dysplasia-2b Fibular Aplasia-Complex Brachydactyly Syndrome
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 Melanoma, Malignant CMM1 Melanoma, Cutaneous Malignant Cmm Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS18382	Cdk10 Mouse Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDK10	RGD	RGD:1304851
Macaca mulatta	CDK10	VGNC	VGNC:99499
Canis familiaris	CDK10	VGNC	VGNC:39043
Bos taurus	CDK10	VGNC	VGNC:27116
Felis catus	CDK10	VGNC	VGNC:60693
Mus musculus	CDK10	MGD	MGI:2448549
Others	CDK10	NCBI