CDK10 Antibody (YA9984)
(Synonyms: Cyclin-dependent kinase 10, Cell division protein kinase 10, Serine/threonine-protein kinase PISSLRE, CDK10)CDK10 Antibody (YA9984) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to CDK10.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 50% glycerol, 0.05% BSA and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000-2000 |
Product Details
CDK10 Antibody (YA9984) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to CDK10.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 46, 34 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 41, 32, 21, 17 kDa
Synthetic peptide corresponding to the C-term region of human CDK10.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 50% glycerol, 0.05% BSA and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CDK10 is a Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling[1][2].
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Subcellular Localization
Cytoplasm, cytoskeleton, cilium basal body
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Isoforms & Post-Translational Modification
CDK10 has 7 isoforms, Q15131-1: amino acid length is 360, molecular weight is 41038 Da (predicted); Q15131-2: amino acid length is 289, molecular weight is 32731 Da (predicted); Q15131-3: amino acid length is 283, molecular weight is 31944 Da (predicted); Q15131-4: amino acid length is 272, molecular weight is 30702 Da (predicted); Q15131-5: amino acid length is 188, molecular weight is 21512 Da (predicted); Q15131-6: amino acid length is 154, molecular weight is 17446 Da (predicted); Q15131-7: amino acid length is 289, molecular weight is 32662 Da (predicted).
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Subunit
Heterodimer with CCNQ, the interaction is required for kinase activity.
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SwissProt ID
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Synonyms
Cyclin-dependent kinase 10, Cell division protein kinase 10, Serine/threonine-protein kinase PISSLRE, CDK10
Documentation
[1]. Guen VJ, et al. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19525-30. [Content Brief]
[2]. Guen VJ, et al. STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis. Cell Cycle. 2016;15(5):678-88. [Content Brief]
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