Referencia número: HY-13627

Estramustine phosphate sodium

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Estramustine phosphate sodium, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate sodium depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate sodium can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer.

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Pureza: 99.60%
No. CAS: 52205-73-9
Fòrmula: C₂₃H₃₀Cl₂NNa₂O₆P
Peso molecular:564.35

Almacenamiento:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Estramustine phosphate sodium Chemical Structure

No. CAS: 52205-73-9

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Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	16 μM Compound: Estramustine Phosphate Sodium	Antimitotic activity against human DU-145 cells assessed as reduction in cell proliferation incubated for 72 hrs by alamar blue based fluorescence spectrophotometric analysis Antimitotic activity against human DU-145 cells assessed as reduction in cell proliferation incubated for 72 hrs by alamar blue based fluorescence spectrophotometric analysis	[PMID: 37948954]

In Vitro

Estramustine phosphate sodium (1 µg/ mL, 48 h) suppresses PC3 cell growth^[1].
Estramustine phosphate sodium (2 µg/mL, 48 h) elevates phosphatidylserine eversion amount on PC3 cells and induces PC3 cell apoptosis through reducing miR-31^[1].
Estramustine phosphate sodium (0-40 µM, 24-72 h) inhibits cell proliferation and tubulin cytoskeleton in RAW 264.7 cells^[2].
Estramustine phosphate sodium (10 µM, 24 h) inhibits TGF-β-induced RAW 264.7 cell migration, as well as TGF-β-induced uPA production by inhibiting Smad3 activation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PC3 cells
Concentration:

1 µg/ mL
Incubation Time:

48 h
Result:

Suppressed PC3 cell growth.

Immunofluorescence^[2]

Cell Line:

RAW 264.7 cells
Concentration:

10 µM
Incubation Time:

24 h
Result:

Disrupted the interphase microtubules.

Cell Migration Assay ^[2]

Cell Line:

18 h of TGF-β treated RAW 264.7 cells
Concentration:

10 µM
Incubation Time:

24 h
Result:

Inhibited TGF-β-Induced Cell Migration.

In Vivo

Estramustine phosphate sodium (Intraperitoneal injection, 4 or 12 mg/kg, a daily dose for 2 weeks) inhibits PAC120 tumor growth 53% by day 35^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss nu/nu (nude) male mice (5-week-old) bearing PAC120 tumors^[3]
Dosage:

4 mg/kg, 12 mg/kg
Administration:

Intraperitoneal injection; daily; for 2 weeks
Result:

Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.

Animal Model:

Human prostate cancer xenograft PAC120^[3]
Dosage:

4 or 12 mg/kg, a daily dose for 2 weeks.
Administration:

Intraperitoneal injection
Result:

Inhibited PAC120 tumor growth 53% by day 35.

Chemical Information

No. CAS 52205-73-9
Appearance Solid
Peso molecular 564.35
Fòrmula C₂₃H₃₀Cl₂NNa₂O₆P
Color White to off-white
SMILES

O=C(N(CCCl)CCCl)OC1=CC2=C(C=C1)[C@@]3([H])CC[C@@]4(C)[C@](CC[C@@H]4OP(O[Na])(O[Na])=O)([H])[C@]3([H])CC2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (1)

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Journal Impact Factor

Cell Rep Med

CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer. [Abstract]

2025 Apr 15;6(4):102053. PMID: 40187357

Solvente y solubilidad

In Vitro:

H₂O : 62.5 mg/mL (110.75 mM; Need ultrasonic)

DMSO : 5 mg/mL (8.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7720 mL

8.8598 mL

17.7195 mL

5 mM

0.3544 mL

1.7720 mL

3.5439 mL

10 mM

0.1772 mL

0.8860 mL

1.7720 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (278 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. C Wei, et al. Estramustine phosphate induces prostate cancer cell line PC3 apoptosis by down-regulating miR-31 levels. Eur Rev Med Pharmacol Sci. 2018 Jan;22(1):40-45. [Content Brief]

[2]. Sonja S Mojsilovic, et al. Estramustine Phosphate Inhibits TGF- β-Induced Mouse Macrophage Migration and Urokinase-Type Plasminogen Activator Production. Anal Cell Pathol (Amst). 2018 Sep 2;2018:3134102. [Content Brief]

[3]. Stephane Oudard, et al. Activity of docetaxel with or without estramustine phosphate versus mitoxantrone in androgen dependent and independent human prostate cancer xenografts. J Urol. 2003 May;169(5):1729-34. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	1.7720 mL	8.8598 mL	17.7195 mL	44.2988 mL
DMSO / H₂O	5 mM	0.3544 mL	1.7720 mL	3.5439 mL	8.8598 mL
H₂O	10 mM	0.1772 mL	0.8860 mL	1.7720 mL	4.4299 mL
	15 mM	0.1181 mL	0.5907 mL	1.1813 mL	2.9533 mL
	20 mM	0.0886 mL	0.4430 mL	0.8860 mL	2.2149 mL
	25 mM	0.0709 mL	0.3544 mL	0.7088 mL	1.7720 mL
	30 mM	0.0591 mL	0.2953 mL	0.5907 mL	1.4766 mL
	40 mM	0.0443 mL	0.2215 mL	0.4430 mL	1.1075 mL
	50 mM	0.0354 mL	0.1772 mL	0.3544 mL	0.8860 mL
	60 mM	0.0295 mL	0.1477 mL	0.2953 mL	0.7383 mL
	80 mM	0.0221 mL	0.1107 mL	0.2215 mL	0.5537 mL
	100 mM	0.0177 mL	0.0886 mL	0.1772 mL	0.4430 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Estramustine phosphate sodium

1 Cited Publications

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Estramustine phosphate sodium

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Publications Citing Use of MedChemExpress (MCE) Estramustine phosphate sodium

Actividad biológica

Chemical Information

Publications (1)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Estramustine phosphate sodium Related Classifications

HY-13627 Related Classifications