Lexacalcitol
Lexacalcitol (KH1060), a vitamin D analog, is a potent regulator of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases.
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- No. CAS: 131875-08-6
- Fòrmula: C29H48O4
- Peso molecular:460.69
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Almacenamiento:
-20°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-10001
CalcipotriolVitamin D3 Analog -
HY-32343
SecalciferolVitamin D Metabolite -
HY-15439
(24S)-24,25-Dihydroxyvitamin D3Vitamin D3 Inactive Form -
HY-75958
Vitamin D4VD/VDR Activator -
HY-10003
AlfacalcidolVDR Activator -
HY-32351
CalcifediolVDR Ligand -
HY-32348
DoxercalciferolVD/VDR Activator -
HY-50919
ParicalcitolVitamin D Receptor Agonist -
HY-A0020
EldecalcitolVitamin D Analogue -
HY-32341
SeocalcitolVitamin D Agonist -
HY-32342
FalecalcitriolVD/VDR Activator -
HY-32339
MaxacalcitolVDR Agonist
Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | ED50 |
0.27 nM
Compound: 3 (KH-1060)
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In vitro activity on human breast adenocarcinoma cell line MCF-7 proliferation
In vitro activity on human breast adenocarcinoma cell line MCF-7 proliferation
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[PMID: 11000014] |
In Vitro
Lexacalcitol inhibits cell proliferation by 50% at 10-12 M (14,000 times more active than la,25(OH)2D3) in human histiocytic lymphoma cell line U 937[1].
Lexacalcitol inhibits interleukin-1-induced mouse thymocyte proliferation by 50% at 3×10-16 M , allogeneic stimulation of mouse spleen lymphocytes at 5×10-15 M[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male and female spontaneously diabetic NOD mice[2]
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Dosage:0.5 mg/kg/2 days
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Administration:Intraperitoneal injection
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Result:Single treatment with KH1060 or CyA did not result in statistically significant suppression of early graft failure, while the combination of KH1060 and CyA can prevent early graft failure and delay graft rejection of xenogeneic islets in spontaneously diabetic NOD mice.
Chemical Information
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No. CAS 131875-08-6
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Appearance Solid
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Peso molecular 460.69
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Fòrmula C29H48O4
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Color White to off-white
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SMILES
C[C@]1(CCC/2)[C@](CC[C@@H]1[C@@H](C)OCCCC(CC)(CC)O)([H])C2=C\C=C(C[C@@H](O)C[C@@H]3O)/C3=C
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Synonyms
KH1060
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. L Binderup, et al. 20-epi-vitamin D3 analogues: a novel class of potent regulators of cell growth and immune responses. Biochem Pharmacol. 1991 Sep 27;42(8):1569-75. [Content Brief]
[2]. C Gysemans, et al. A combination of KH1060, a vitamin D(3) analogue, and cyclosporin prevents early graft failure and prolongs graft survival of xenogeneic islets in nonobese diabetic mice. Transplant Proc. 2001 May;33(3):2365. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lexacalcitol Related Classifications
HY-32340 Related Classifications
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