BMS-317180
BMS-317180 is an orally active and potent growth hormone secretagogue receptor (GHS-R) agonist (EC50=7.9 nM). BMS-317180 stimulates endogenous growth hormone (GH) release. BMS-317180 is promising for research of age-related frailty, osteoporosis, and cancer cachexia.
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- No. CAS: 295337-71-2
- Fòrmula: C21H33N7O5
- Peso molecular:463.53
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| H4 | EC50 |
1.9 nM
Compound: 2, BMS-317180
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Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay
Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay
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[PMID: 17973363] |
| H4 | EC50 |
1.9 nM
Compound: 4, BMS-317180
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Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay
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[PMID: 18378446] |
Chemical Information
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No. CAS 295337-71-2
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Peso molecular 463.53
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Fòrmula C21H33N7O5
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SMILES
O=C(NCCCCO)OCCN1N=NN=C1[C@@H](COCC2=CC=CC=C2)NC(C(N)(C)C)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-317180 Related Classifications
HY-119125 Related Classifications
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