CHIR-98023
CHIR-98023 is a potent, selective and reversible inhibitor of GSK3, with IC50s of 10 nM and 6.7 nM for GSK3α and GSK3β, respectively. CHIR-98023 can improve insulin action and glucose metabolism.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 252916-76-0
- Fòrmula: C20H16Cl2N8O2
- Peso molecular:471.30
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
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GSK-3β inhibitor 1GSK-3β Inhibitor
Actividad biológica
Descripciòn
IC50 & Target
[1]|
GSK3α 10 nM (IC50) |
GSK3β 6.7 nM (IC50) |
Chemical Information
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No. CAS 252916-76-0
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Peso molecular 471.30
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Fòrmula C20H16Cl2N8O2
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SMILES
O=[N+](C1=CN=C(NCCNC2=NC=C(C3=NC=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2)C=C1)[O-]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Cline GW, et, al. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats. Diabetes. 2002 Oct;51(10):2903-10. [Content Brief]
[2]. Hu M, et, al. Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells. J Neurochem. 2008 Aug;106(3):1371-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CHIR-98023 Related Classifications
HY-126125 Related Classifications
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