Circulin B
Circulin B is a macrocyclic plant cyclopeptide. Circulin B functions as a plant defense peptide and exhibits antibacterial and anti-HIV activities. Circulin B has high binding affinity for the envelope protein of dengue virus, showing potential anti-dengue virus activity. Circulin B can be used in studies related to dengue virus infection, human immunodeficiency virus infection and microbial infection.
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- No. CAS: 20905-50-4
- Fòrmula: C52H98N16O13
- Peso molecular:1155.43
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
199 μg/mL
Compound: Polymyxin E2-Ile
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Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
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[PMID: 29412662] |
In Vitro
Circulin B exhibits non-allergenic and non-toxic properties in in silico profiling[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 20905-50-4
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Peso molecular 1155.43
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Fòrmula C52H98N16O13
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SMILES
CC(C)CCCCC(N[C@@H](CCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCN)C(N[C@@H]1C(N[C@H](C(N[C@@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@@](C(NCC1)=O)([H])[C@H](O)C)=O)CCN)=O)CCN)=O)([H])[C@@H](C)CC)=O)CC(C)C)=O)CCN)=O)=O)=O)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Reena G, et al. In silico screening of plant peptides against the envelope protein of dengue virus. Trop Biomed. 2023;40(2):124-128. [Content Brief]
[2]. Balaraman S, et al. The structural and functional reliability of Circulins of Chassalia parvifolia for peptide therapeutic scaffolding. J Cell Biochem. 2018;119(5):3999-4008. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Circulin B Related Classifications
HY-182588 Related Classifications
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Keywords
- Circulin B
- 20905-50-4
- Bacterial
- HIV
- Dengue Virus
- microbial infections
- dengue virus envelope protein
- fusion inhibition activity
- dengue virus infection
- human immunodeficiency virus infection
- human immunodeficiency virus
- *Chassalia parvifolia*
- intramolecular interactions
- plant defensive peptide
- antimicrobial activity
- Inhibitor
- inhibitor
- inhibit