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Referencia número: HY-125790

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Cyclazocine

Cyclazocine is a μ, δ, and κ opioid receptor modulator with K_i values of 0.32, 1.1, and 0.18 nM, respectively. Cyclazocine exhibits "mixed" pharmacological activities, acting as a μ-partial antagonist, κ-agonist, and low-affinity δ ligand. Cyclazocine shows antinociceptive activity in mice. Cyclazocine can be used in studies on psychoactive substance addiction.

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No. CAS: 3572-80-3
Fòrmula: C₁₈H₂₅NO
Peso molecular:271.40

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Please store the product under the recommended conditions in the Certificate of Analysis.

Cyclazocine Chemical Structure

No. CAS: 3572-80-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

IC₅₀ & Target^[1]

μ Opioid Receptor/MOR

0.32 nM (Ki)

κ Opioid Receptor/KOR

1.1 nM (Ki)

δ Opioid Receptor/DOR

0.18 nM (Ki)

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In Vitro

Cyclazocine potently binds to μ, δ, and κ opioid receptors in guinea pig brain cell membranes, with K_i values of 0.32 nM, 1.1 nM, and 0.18 nM, respectively^[1].
Cyclazocine potently binds to the human μ-opioid receptor stably expressed in CHO cells, with a K_i value of 0.16 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cyclazocine (1 mg/kg; i.p.; single dose) administered in mice exhibits antinociceptive activity with a 2-hour duration of action^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3572-80-3
Peso molecular 271.40
Fòrmula C₁₈H₂₅NO
SMILES

OC1=CC=C2C(C3(CCN(C(C3C)C2)CC4CC4)C)=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Wentland MP, et al. Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 3: 8-Thiocarboxamido and 8-thioformamido derivatives of cyclazocine. Bioorg Med Chem Lett. 2005;15(10):2547-2551. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Cyclazocine

Ver todos los productos específicos de isoformas Opioid Receptor

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Cyclazocine Related Classifications

HY-125790 Related Classifications