EGFR-IN-141
EGFR-IN-141 (Compound 8I) is the inhibitor for EGFR with an IC50 of 2.67 nM. EGFR-IN-141 exhibits cytotoxicity in cancer cell A549 with an IC50 of 13.75 μM. EGFR-IN-141 induces apoptosis and mitochondrial membrane depolarization, and exhibits potential antitumor efficacy.
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- No. CAS: 3054263-27-0
- Fòrmula: C20H15FN8O2S2
- Peso molecular:482.51
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
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EGFR 2.67 nM (IC50) |
Chemical Information
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No. CAS 3054263-27-0
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Peso molecular 482.51
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Fòrmula C20H15FN8O2S2
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SMILES
O=C1C2=C(N=CN1CC3=NN=C(N3N)SCC(NC4=NC5=C(S4)C=C(F)C=C5)=O)C=CC=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)